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A study on the mode of action of clinically relevant antimicrobial peptides

Tese de doutoramento, Bioquímica (Biofísica Molecular), Universidade de Lisboa, Faculdade de Ciências, 2010 ; The antimicrobial peptides (AMPs) omiganan (ILRWPWWPWRRK– NH2) and BP100 (KKLFKKILKYL–NH2) were biophysically studied with bacterial and mammalian cell membrane models, essentially using optical spectroscopy techniques. Peptide-membrane binding was interpreted under a Nernst partition formalism. Both p...