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Conteúdo em flavonóides e fenóis totais e actividade antioxidante de extractos ...
Melo, M. N.; Costa, D. D.; Santos, M. C.; Oliveira, V.; Saraiva, J. A.; Cunha, Â.; Almeida, A.Resumo indisponível.
Crescimento e nutrição mineral de Ipomoea nil
Duarte,D. J.; Bianco,S.; Melo,M. N.; Carvalho,L.B.Um experimento em casa de vegetação foi conduzido entre novembro de 2005 e abril de 2006, na UNESP, campus de Jaboticabal, SP, objetivando estudar a produção de massa seca, a distribuição e o acúmulo de macronutrientes por Ipomoea nil, uma importante infestante de culturas anuais e perenes no Brasil. As plantas foram cultivadas em vasos de 7 litros com substrato de areia e irrigadas diariamente com solução nutr...
Hepatic granulomas in canine visceral leishmaniasis and clinical status
Sant’Ana,J.A.P.; Lima,W.G.; Oliveira,M.R.; Simões,L.A.; Michalick,M.S.M.; Melo,M.N.; Tafuri,W.L.; Tafuri,Wg.L.The histopathological description of intralobular hepatic granulomas in animals with a defined clinical status (asymptomatic, oligosymptomatic and symptomatic animals) was reported. Seventy-one mongrel dogs naturally infected with Leishmania chagasi were obtained from two Brazilian endemic areas: João Pessoa, PB and Belo Horizonte, MG. The hepatic parasite load was determined and compared to granuloma formation...
Pharmacokinetic and parasitological evaluation of the bone marrow of dogs with ...
Schettini,D.A.; Costa Val,A.P.; Souza,L.F.; Demicheli,C.; Rocha,O.G.F.; Melo,M.N.; Michalick,M.S.M.; Frézard,F.The aim of the present study was to evaluate the impact of a multiple dose regimen of a liposomal formulation of meglumine antimoniate (LMA) on the pharmacokinetics of antimony in the bone marrow of dogs with visceral leishmaniasis and on the ability of LMA to eliminate parasites from this tissue. Dogs naturally infected with Leishmania chagasi received 4 intravenous doses of either LMA (6.5 mg antimony/kg body...
Distribution of liposome-encapsulated antimony in dogs
Schettini,D.A.; Costa Val,A.P.; Souza,L.F.; Demicheli,C.; Rocha,O.G.F.; Melo,M.N.; Michalick,M.S.M.; Frézard,F.The achievement of complete cure in dogs with visceral leishmaniasis is currently a great challenge, since dogs are the main reservoir for the transmission of visceral leishmaniasis to humans and they respond poorly to conventional treatment with pentavalent antimonials. In order to improve the efficacy of treatment, we developed a novel formulation for meglumine antimoniate based on the encapsulation of this d...
The change of behavior of two strains of Leishmania after cultivation in a defi...
Melo,M. N.; Williams,Paul; Rocha,N. M. Magalhães; Babá,E. H.; Mayrink,W.; Michalick,M. S. M.; Costa,C. A da; Dias,M.; Magalhães,P. A.Attempts have been made to characterize two strains of Leishmania that became infective to golden hamsters only after they had been maintained for several years in a chemically defined culture medium. Observations were made on the growth rates of promastigotes in vitro, course of infection in hamsters, morphology of amastigotes, and electrophoretic mobility patterns of eight isoenzymes. Information was obtained...
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