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Effect of chaethomellic acid on renal function in rat model of chronic renal fa...
Nogueira, António José M.; Mega, Carmén; Fonte, Elizabete; Oliveira, Paula; Colaço, Bruno; López-Novoa, Jose; Colaço, Aura; Pires, MariaTo study the effect of chronic treatment with chaethomellic acid (CA), a highly specific inhibitor of ras farnesyl-protein transferase, on the renal function of rats with renal failure induced by renal mass reduction. Male Wistar rats were subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been placed in four experimental groups: RMR: rats without treat- ment (n=13); RMR...
Effect of chaethomellic acid on renal function in a rat model of chronic renal ...
Nogueira, António José M.; Fonte, Elizabete; Oliveira, Paula; Colaço, Bruno; López-Novoa, Jose; Mega, Carmén; Colaço, Aura; Pires, MariaTo study the effect of chronic treatment with chaethomellic acid (CA), a highly specific inhibitor of ras farnesyl-protein transferase, on the renal function of rats with renal failure induced by renal mass reduction. Male Wistar rats were subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been placed in four experimental groups: RMR: rats without treat- ment (n=13); RMR...
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