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Hormones and their Functions in the Dog. From the Cell to Hormone and from Horm...

Animal bodies represent one of the more complex and perfect systems of nature but despite its complexity and functionality, the control of its basic functions is performed by only two systems: the nervous system and the endocrine system. Reproduction, gestation, muscle contraction, nutrient digestion and absorption, hydroelectrolytic balance, haematopoiesis and so many other bodily functions, are directly or in...

Sitagliptin treatment prevented pancreatic lesions evolution in a rat modelo f ...

Background: This study aimed to elucidate mechanisms underlying the protective effects of sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, against pancreatic lesions, in an animal model of T2DM. Methods: Male obese diabetic ZDF (fa/fa) rats, 20-weeks-old, were treated with vehicle or sitagliptin (10mg/kg BW/day) for 6 weeks, and compared with lean control littermates (n=8/each). Biochemical parameters ...

Age influence in BBN induced urothelial lesions in ICR male mice

Pancreatic lesions and metabolic aggravation are prevented by low doses of sita...

Introduction: The management of type 2 diabetes is designed to reduce disease-related complications and improve long-term outcomes. Inhibition of dipeptidyl peptidase-4 (DPP-4) activity by sitagliptin has been shown to improve glycaemic control in patients with type 2 diabetes Mellitus (T2DM) by prolonging the actions of incretin hormones, but the real impact of low-dose sitagliptin treatment on cardiometabolic...

Renal structure modification in an animal model of type 2 diabetes with aging: ...

Background and aims: The Zucker Diabetic Fatty (ZDF-fa/fa) rat is one of the most used models for the study of type 2 diabetes (T2DM). Characterization of renal morphology in this model may provide useful insights into the mechanism of diabetic nephropathy progression. The purpose of the present study was to determine renal morphology, identify and characterize renal dysfunction complications such as hydronephr...

Intoxicações nos animais de companhia

Os animais de companhia são expostos, muito frequentemente, a produtos tóxicos. Estes são os agentes que provocam envenenamento e podem ser colocados em contacto com o animal de forma acidental ou mesmo propositadamente. A maioria das intoxicações nas espécies canina e felina acontecem por falta de informação dos proprietários, pelo que devem ser aplicadas estratégias educacionais de forma a evitar estas si...

Tétano em animais de companhia

O tétano é uma doença infecciosa, causada pela acção patogénica de toxinas produzidas por uma bactéria anaeróbia, Gram+: Clostridium tetani. Quase todos os mamíferos são susceptíveis, apesar de os cães serem relativamente resistentes e de os gatos serem muito mais resistentes que qualquer outr

Biochemical and histological effects of sitagliptin on Zucker Diabetic Fatty ra...

Background: Inhibition of dipeptidyl peptidase-4 (DPP-4) activity by sitagliptin has been shown to improve glycemic control in patients with type 2 diabetes Mellitus (T2DM) by prolonging the actions of incretin hormones, but the really impact of low-dose sitagliptin treatment on pancreas lesions is almost unknown. This study aimed to evaluate the effects of sitagliptin on biochemical and histological (pancreas)...