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Hepatic gluconeogenesis and Krebs cycle fluxes in a CCl4 model of acute liver f...
Carvalho, Rui A.; Jones, John G.; McGuirk, Chris; Sherry, A. Dean; Malloy, Craig R.Acute liver failure was induced in rats by CCl4 administration and its effects on the hepatic Krebs cycle and gluconeogenic fluxes were evaluated in situ by 13C NMR isotopomer analysis of hepatic glucose following infusion of [U-13C]propionate. In fed animals, CCl4 injury caused a significant increase in relative gluconeogenic flux from 0.80 ± 0.10 to 1.34 ± 0.24 times the flux through citrate synthase (p < 0.0...
Data: 2002
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Origem: Estudo Geral - Universidade de Coimbra
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