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Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1b

The serrated pathway to colorectal tumor formation involves oncogenic mutations in the BRAF gene which are sufficient for initiation of hyperplastic growth but not for tumor progression. The analysis of colorectal tumors revealed that overexpression of splice variant Rac1b occurs in around 80% of tumors with mutant B-Raf and both events were shown to cooperate in tumor cell survival. Here we provide evidence fo...

A novel Rac1/PAK1/BCL-6/STAT5 pathway modulates the expression of cell-cycle-as...

Gene expression depends on binding of transcriptional regulators to gene promoters, a process controlled by signalling pathways. The transcriptional repressor BCL-6 downregulates genes involved in cell cycle progression and becomes inactivated following phosphorylation by the Rac1 GTPase activated protein kinase PAK1. Interestingly, the DNA motifs recognized by BCL-6 and STAT5 are similar. Because STAT5 stimula...

Ibuprofen prevents inflammation-induced increase in Rac1 expression and growth ...

Realização em tecnologia monolítica de Arsenieto de Gálio (GaAs MMIC) de amplif...

Nowadays the clock recovery circuits used for frequencies up to 10 Gbit/s use open-loop structures. The band-pass filters used on these structures are implemented with dielectric resonators (DR). This kind of filters introduce spurious modes that degradate the characteristics of the recovered clock signal. So, the clock amplification stage is required not only to provide the desired clock signal levels, but als...

Rac1 signalling modulates a STAT5/BCL-6 transcriptional switch on cell cycle-as...

Gene expression depends on binding of transcriptional regulators to gene promoters, a process controlled by signalling pathways. The transcriptional repressor B-cell lymphoma (BCL)-6 downregulates genes involved in cell-cycle progression and becomes inactivated following phosphorylation by the Rac1 GTPase-activated protein kinase PAK1. Interestingly, the DNA motifs recognized by BCL-6 and signal transducers and...

Alternative splicing of tumour-related rac1b is regulated by upstream signallin...

The small GTPase Rac1 regulates signalling pathways controlling actin-dependent cell motility as well as gene transcription. Analternative splicing variant Rac1b is overexpressed in a subset of colorectal tumours and cooperates with mutant B-Raf to sustain tumour cellviability. The alternative splicing mechanism regulating Rac1b expression involves two antagonistic splicing factors, ASF/SF2 and SRp20. Using aRa...

Rac1 signalling modulates a STAT5/BCL-6 transcriptional switch on cell-cycle-as...

Gene expression depends on binding of transcriptional regulators to gene promoters, a process controlled by signalling pathways. The transcriptional repressor BCL-6downregulates genes involved in cell cycle progression and becomes inactivated following phosphorylation by the Rac1 GTPase activated protein kinase PAK1.Interestingly, the DNA motifs recognized by BCL-6 and STAT5 are similar. Because STAT5 stimulati...

Transcriptional regulation by antagonistic promoter binding of BCL-6 or Stat5 i...

Selected for oral presentation.

The influence of residual stresses on the fatigue behaviour of 2024-T3 Al speci...

Dissertação apresentada para obtenção do grau de Mestre em Engenharia Mecânica, na Faculdade de Engenharia da Universidade do Porto, sob a orientação dos Professores Paulo Manuel Salgado Tavares de Castro e Artur Portela

Antagonistic Regulation of Cystic Fibrosis Transmembrane Conductance Regulator ...

Members of the WNK (with-no-lysine [K]) subfamily of protein kinases regulate various ion channels involved in sodium, potassium, and chloride homeostasis by either inducing their phosphorylation or regulating the number of channel proteins expressed at the cell surface. Here, we describe findings demonstrating that the cell surface expression of the cystic fibrosis transmembrane conductance regulator (CFTR) is...