Encontrados 11 documentos, a visualizar página 1 de 2
Monocarboxylate transporters (MCTs) in gliomas : expression and exploitation as...
Gonçalves, Vera M.; Honavar, Mrinalini; Pinheiro, Céline; Martinho, Olga; Pires, Manuel Melo; Pinheiro, Célia; Cordeiro, Michelle; Bebiano, GilBackground. Gliomas exhibit high glycolytic rates, and monocarboxylate transporters (MCTs) play a major role in the maintenance of the glycolytic metabolism through the proton-linked transmembrane transport of lactate. However, their role in gliomas is poorly studied. Thus, we aimed to characterize the expression of MCT1, MCT4, and their chaperone CD147 and to assess the therapeutic impact of MCT inhibition in...
The Monocarboxylate Transporter Inhibitor α-Cyano-4-Hydroxycinnamic Acid Disrup...
Granja, Sara Costa; Santos, Filipa Morais; Gonçalves, Vera M.; Ferreira, Manuel Viana; Nogueira, Rosete; Silva, Cristina Nogueira; Pinto, Jorge CorreiaBACKGROUND/AIMS: The human embryo develops in a hypoxic environment. In this way, cells have to rely on the glycolytic pathway for energy supply, leading to an intracellular accumulation of monocarboxylates such as lactate and pyruvate. These acids have an important role in cell metabolism and their rapid transport across the plasma membrane is crucial for the maintenance of intracellular pH homeostasis. This...
RKIP Inhibition in cervical cancer Is associated with higher tumor aggressive b...
Martinho, Olga; Pinto, Filipe; Granja, Sara Costa; Gonçalves, Vera M.; Longatto Filho, Adhemar; Reis, R. M.; Loreto, Celso di; Rosner, Marsha R.Cervical cancer is one of the most common cancers in women worldwide, being high-risk group the HPV infected, the leading etiological factor. The raf kinase inhibitory protein (RKIP) has been associated with tumor progression and metastasis in several human neoplasms, however its role on cervical cancer is unclear. In the present study, 259 uterine cervix tissues, including cervicitis, cervical intraepithelial ...
In vitro and in vivo analysis of RTK inhibitor efficacy and identification of i...
Martinho, Olga; Oliveira, Renato Silva; Gonçalves, Vera M.; Clara, Carlos; Almeida, José Reynaldo; Carvalho, André Lopes; Barata, João TabordaTreatment for glioblastoma consists of radiotherapy and temozolomide-based chemotherapy. However, virtually all patients recur, leading to a fatal outcome. Receptor tyrosine kinase (RTK)-targeted therapy has been the focus of attention in novel treatment options for these patients. Here, we compared the efficacy of imatinib, sunitinib, and cediranib in glioblastoma models. In the present work, the biologic effe...
Angiogenic potential of gellan gum-based hydrogels for application in nucleus p...
Correia, Joana Silva; Gonçalves, Vera M.; Salgado, A. J.; Sousa, Nuno; Oliveira, Joaquim M.; Reis, R. M.; Reis, R. L.Hydrogels for nucleus pulposus (NP) regeneration should be able to comprise a nonangiogenic or even antiangiogenic feature. Gellan gum (GG)–based hydrogels have been reported to possess adequate properties for being used as NP substitutes in acellular and cellular strategies, due to its ability to support cell encapsulation, adequate mechanical properties, and noncytotoxicity. In this study, the angiogenic resp...
Advanced mimetic materials for meniscus tissue engineering : targeting segmenta...
Correia, Joana Silva; Pereira, H.; Yan, Leping; Gonçalves, Vera M.; Oliveira, A. L.; Oliveira, Joaquim M.; Reis, R. M.; Mendes, João EspregueiraMeniscus lesions are among the most common orthopaedic injuries which can ultimately lead to degeneration of the knee articular cartilage. The human meniscus has a limited healing potential, partly due to a poor vasculature, and thus meniscus regeneration using tissue engineering strategies has recently been investigated as a promising alternative to total/partial meniscectomy [1]. Advanced scaffolds for tissue...
Downregulation of RKIP is associated with poor outcome and malignant progressio...
Martinho, Olga; Granja, Sara Costa; Jaraquemada, Teresa; Caeiro, Cláudia; Gonçalves, Vera M.; Honavar, Mrinalini; Costa, Paulo; Damasceno, MargaridaMalignant gliomas are highly infiltrative and invasive tumors, which precludes the few treatment options available. Therefore, there is an urgent need to elucidate the molecular mechanisms underlying gliomas aggressive phenotype and poor prognosis. The Raf Kinase Inhibitory protein (RKIP), besides regulating important intracellular signaling cascades, was described to be associated with progression, metastasis ...
Methacrylated gellan gum hydrogels for application in nucleus pulposus regenera...
Correia, Joana Silva; Gonçalves, Vera M.; Oliveira, Joaquim M.; Reis, R. M.; Reis, R. L.Natural-based hydrogels have been attracting great deal of attention for tissue engineering of nucleus pulposus (NP). Gellan gum is an extracellular microbial polysaccharide from Sphingomonas elodea that forms a firm and transparent gel with interesting features for use as an in vitro 3D cell support, or as an in vivo injectable system. Recently, gellan gum-based hydrogels (ionic- and photocrosslinked methacryl...
In vivo study on the angiogenic potential of gellan gum-based hydrogels for app...
Correia, Joana Silva; Gonçalves, Vera M.; Oliveira, Joaquim M.; Reis, R. M.; Reis, R. L.Tissue engineering of nucleus pulposus (NP) offers a promising alternative strategy to current ineffective clinical approaches for treating intervertebral disc degeneration. Gellan gum-based hydrogels (ionic- and photo-crosslinked methacrylated gellan gum) have been recently proposed as potential candidates for NP regeneration. An important feature of these hydrogels will be their capacity to control blood vess...
Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated wit...
Pértega-Gomes, Nelma; Vízcaíno, Ramón; Gonçalves, Vera M.; Pinheiro, Céline; Silva, Joana; Pereira, Helena; Monteiro, Pedro; Henrique, Rui M.BACKGROUND. Monocarboxylate transporters (MCTs) are transmembrane proteins involved in the transport of monocarboxylates across the plasma membrane, which appear to play an important role in solid tumours, however the role of MCTs in prostate cancer is largely unknown.The aim of the present work was to evaluate the clinico-pathological value of monocarboxylate transporters (MCTs) expression, namely MCT1, MCT2 a...
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