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Towards Targeted MRI: New MRI Contrast Agents for Sialic Acid Detection
Frullano, Luca; Rohovec, Jan; Aime, Silvio; Maschmeyer, Thomas; Prata, M. Isabel; Lima, J. J. Pedroso de; Geraldes, Carlos F. G. C.; Peters, Joop A.The detection of sialic acid in living systems is of importance for the diagnosis of several types of malignancy. We have designed and synthesized two new lanthanide ion ligands (L1 and L2) that are capable of molecular recognition of sialic acid residues. The basic structure of these ligands consists of a DTPA-bisamide (DTPA, diethylenetriamine pentaacetic acid) whose amide moieties each bear both a boronic fu...
Lanthanide(III) Complexes of Novel Mixed Carboxylic-Phosphorus Acid Derivatives...
Kotek, Jan; Lebduscaronková, Petra; Hermann, Petr; Elst, Luce Vander; Muller, Robert N.; Geraldes, Carlos F. G. C.; Maschmeyer, Thomas; Lukescaron, IvanThree novel phosphorus-containing analogues of H5DTPA (DTPA = diethylenetriaminepentaacetate) were synthesised (H6L1, H5L2, H5L3). These compounds have a -CH2-P(O)(OH)-R function (R = OH, Ph, CH2NBn2) attached to the central nitrogen atom of the diethylenetriamine backbone. An NMR study reveals that these ligands bind to lanthanide(III) ions in an octadentate fashion through the three nitrogen atoms, a P-O oxyg...
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