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Sitagliptin delays progression of renal lesions in a rodent model of type 2 dia...
Cristina, M.; Vala, Helena; Oliveira, J.; Fernandes, R.; Mascarenhas-Melo, F.; Parada, B.; Pinto, R.; Teixeira, F.; Reis, F.; Teixeira de Lemos, E.
Pancreatic lesions and metabolic aggravation are prevented by low doses of sita...
Mega, C.; Vala, Helena; Oliveira, J.; Fernandes, R.; Mascarenhas-Melo, F.; Parada, B.; Pinto, R.; Teixeira, F.; Teixeira de Lemos, E.; Reis, F.Introduction: The management of type 2 diabetes is designed to reduce disease-related complications and improve long-term outcomes. Inhibition of dipeptidyl peptidase-4 (DPP-4) activity by sitagliptin has been shown to improve glycaemic control in patients with type 2 diabetes Mellitus (T2DM) by prolonging the actions of incretin hormones, but the real impact of low-dose sitagliptin treatment on cardiometabolic...
Renal structure modification in an animal model of type 2 diabetes with aging: ...
Mega, C.; Vala, Helena; Oliveira, J.; Fernandes, R.; Mascarenhas-Melo, F.; Parada, B.; Pinto, R.; Teixeira, F.; Teixeira de Lemos, E.; Reis, F.Background and aims: The Zucker Diabetic Fatty (ZDF-fa/fa) rat is one of the most used models for the study of type 2 diabetes (T2DM). Characterization of renal morphology in this model may provide useful insights into the mechanism of diabetic nephropathy progression. The purpose of the present study was to determine renal morphology, identify and characterize renal dysfunction complications such as hydronephr...
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