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Exploring bioactive properties of marine cyanobacteria Isolated from the Portug...

Costa, Margarida; Garcia, Mónica; Costa-Rodrigues, João; Costa, Maria Sofia; Ribeiro, Maria João; Fernandes, Maria Helena; Barros, Piedade

The oceans remain a major source of natural compounds with potential in pharmacology. In particular, during the last few decades, marine cyanobacteria have been in focus as producers of interesting bioactive compounds, especially for the treatment of cancer. In this study, the anticancer potential of extracts from twenty eight marine cyanobacteria strains, belonging to the underexplored picoplanktonic genera, C...


Antitumor activity of hierridin B, a cyanobacterial secondary metabolite found ...

Leão, Pedro N.; Costa, Margarida; Ramos, Vitor; Pereira, Alban R.; Fernandes, Virginia C.; Domingues, Valentina F.; Gerwick, William H.

Cyanobacteria are widely recognized as a valuable source of bioactive metabolites. The majority of such compounds have been isolated from so-called complex cyanobacteria, such as filamentous or colonial forms, which usually display a larger number of biosynthetic gene clusters in their genomes, when compared to free-living unicellular forms. Nevertheless, picocyanobacteria are also known to have potential to pr...


Antitumor activity of hierridin B, a cyanobacterial secondary metabolite found ...

Leão, Pedro N.; Costa, Margarida; Ramos, Vitor; Pereira, Alban R.; Fernandes, Virgínia C.; Domingues, Valentina F.; Gerwick, William H.

Cyanobacteria are widely recognized as a valuable source of bioactive metabolites. The majority of such compounds have been isolated from so-called complex cyanobacteria, such as filamentous or colonial forms, which usually display a larger number of biosynthetic gene clusters in their genomes, when compared to free-living unicellular forms. Nevertheless, picocyanobacteria are also known to have potential to pr...


Marine cyanobacteria compounds with anticancer properties: a review on the impl...

Costa, Margarida; Costa-Rodrigues, João; Fernandes, Maria Helena; Barros, Piedade; Vasconcelos, Vitor; Martins, Rosário

Marine cyanobacteria have been considered a rich source of secondary metabolites with potential biotechnological applications, namely in the pharmacological field. Chemically diverse compounds were found to induce cytoxicity, anti-inflammatory and antibacterial activities. The potential of marine cyanobacteria as anticancer agents has however been the most explored and, besides cytotoxicity in tumor cell lines,...


Pisolithus sp. P1001 18S ribosomal RNA gene

Santos-Silva, Celeste; Ragonezi, Carla; Klimaszewska, Kristina; Martins, Rosário; Caldeira, Ana; Zavattieri, Amely

http://www.ncbi.nlm.nih.gov/nuccore/HQ896485.1.


The use of ectomycorrhizal fungi to restore root growth during in vitro rooting...

Santos-Silva, Celeste; Louro, Rogério; Ragonezi, Carla; Caldeira, Ana Teresa; Martins, Rosário; Klimaszewska, Kristina; Dias, Luis; Ganhao, Elsa

The ICAAM Institute aims to study Mediterranean forest ecosystems in all aspects. Our Plant Breeding and Biotechnology Laboratory of ICAAM has always been involved in biotechnology of Mediterranean woody species, and has developed various in vitro techniques for vegetative propagation of Quercus and Pinus (Ragonezi et al. 2010, Zavattieri et al. 2009). The power of clonal propagation for the improvement of thes...


Are known cyanotoxins involved in the toxicity of picoplanktonic and filamentou...

Frazão, Bárbara; Martins, Rosário; Vasconcelos, Vitor

Eight marine cyanobacteria strains of the genera Cyanobium, Leptolyngbya, Oscillatoria, Phormidium, and Synechococcus were isolated from rocky beaches along the Atlantic Portuguese central coast and tested for ecotoxicity. Strains were identified by morphological characteristics and by the amplification and sequentiation of the 16S rDNA. Bioactivity of dichloromethane, methanol and aqueous extracts was assessed...


Primary screening of the bioactivity of brackishwater cyanobacteria: toxicity o...

Lopes, Viviana; Fernandez, Nuria; Martins, Rosário; Vasconcelos, Vitor

Cyanobacteria are a diverse group of Gram-negative bacteria that produce an array of secondary compounds with selective bioactivity against vertebrates, invertebrates, plants, microalgae, fungi, bacteria, viruses and cell lines. The aim of this study was to assess the toxic effects of aqueous, methanolic and hexane crude extracts of benthic and picoplanktonic cyanobacteria isolated from estuarine environments, ...


Comparison between Poaceae pollen counts and ambient Phl p 5 concentration in É...

Munhoz, V.W.; Martins, Rosário; Caldeira, Ana Teresa; Antunes, Célia M.; Caeiro, E.; Carvalho, E.; Brandão, Rui

Airborne pollen of grasses (Poaceae family) is the main aeroallergen in many european countries, namely in Portugal. Grasses includes many herbaceous species with an anemophyllous pollination.


Quantificação de Aeroalergénios de Gramíneas por Imunoensaios com Phl p5

Antunes, Célia M.; Brandão, Rui; Martins, Rosário; Caldeira, Ana; Munhoz, W.

O pólen das gramíneas constitui seguramente uma das principais fontes de aeroalergenos atmosféricos a nível europeu, nomeadamente em Portugal. O nível de exposição a este agente é actualmente calculado a partir de contagens polínicas, efectuadas em amostras de ar atmosférico.


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia