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Comparative study of tributyltin toxicity on two bacteria of the genus Bacillus
Martins, J. D.; Jurado, A. S.; Moreno, A. J. M.; Madeira, V. M. C.Tributyltin is a potent biocide mainly used in marine antifouling paints. Owing to its widespread distribution in coast areas and its high toxicity to aquatic organisms, the use of this compound is generally restricted and under government regulation. Despite of that, it persists in the aquatic environment. Organotins used in industry have also been detected in terrestrial environments. The persistence and high...
Use of the microorganism Bacillus stearothermophilus as a model to evaluate tox...
Martins, J. D.; Monteiro, J. P.; Antunes-Madeira, M. C.; Jurado, A. S.; Madeira, V. M. C.Microorganisms are very powerful tools for the supply of information about the toxic effects of lipophilic compounds, since an impairment of cell growth usually occurs as a result of perturbations related, in most cases, with the partition of toxicants in membranes. The thermophilic eubacterium Bacillus stearothermophilus has been used as a model system to identify [alpha]- and [beta]-endosulfan interactions wi...
Molecular mechanisms of the metabolite 4-hydroxytamoxifen of the anticancer dru...
Monteiro, J. P.; Martins, J. D.; Luxo, P. C.; Jurado, A. S.; Madeira, V. M. C.A strain of the thermophilic eubacterium Bacillus stearothermophilus was used as a model system to identify membrane mediated cytotoxic effects of 4-hydroxytamoxifen, following previous studies with tamoxifen. With this experimental approach we attempted to further clarify tamoxifen and 4-hydroxytamoxifen membrane interactions often evoked as responsible for their multiple cellular effects. Bacterial growth and...
Hypertensive crises.
Da Silva, P M; Serviço de Medicina do Hospital de Santa Marta, Lisboa.; Martins, J D; Nobre, F LThe goal of the accurate treatment of an hypertensive crisis is to reduce the critically elevated blood pressure to a safer level, in an hemodynamic point of view, although not necessarily normal. The authors stress that a prompt and correct diagnosis in distinguishing hypertensive emergencies from urgencies, in understanding its pathophysiology and the knowledge of available drugs is essential for a successful...
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