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Ln[DO3A-N-α-(pyrenebutanamido)propionate] complexes: optimized relaxivity and N...

We have proposed recently that the DO3A-N-α-(amino)propionate chelator and its amide conjugates are leads to targeted, high relaxivity, safe contrast agents for magnetic resonance imaging. In this work we illustrate further the expeditious nature and robustness of the synthetic methodologies developed by preparing the DO3A-N-(α-pyrenebutanamido)propionate chelator. Its Gd3+ chelate retains the optimized water e...

Pseudomyxoma peritonei: a clinical case of this poorly understood condition

BACKGROUND: Pseudomyxoma peritonei is an uncommon condition with an estimated incidence of one to two per million (worldwide) per year. It is characterized by the peritoneal deposition of mucinous tumors, most commonly of the appendix, and occasionally from the ovary, coupled by mucinous ascites. CASE PRESENTATION: We report the case of a 76-year-old woman who presented with increased abdominal girth and dyspn...

O Hospital de D. Estefânia e a História da Cirurgia Pediátrica em Portugal

Treatment planning systems dosimetry auditing project in Portugal

BACKGROUND AND PURPOSE: The Medical Physics Division of the Portuguese Physics Society (DFM_SPF) in collaboration with the IAEA, carried out a national auditing project in radiotherapy, between September 2011 and April 2012. The objective of this audit was to ensure the optimal usage of treatment planning systems. The national results are presented in this paper. MATERIAL AND METHODS: The audit methodology simu...

Treatment planning systems dosimetry auditing project in Portugal

BACKGROUND AND PURPOSE: The Medical Physics Division of the Portuguese Physics Society (DFM_SPF) in collaboration with the IAEA, carried out a national auditing project in radiotherapy, between September 2011 and April 2012. The objective of this audit was to ensure the optimal usage of treatment planning systems. The national results are presented in this paper. MATERIAL AND METHODS: The audit methodology simu...

Treatment planning systems dosimetry auditing project in Portugal

BACKGROUND AND PURPOSE: The Medical Physics Division of the Portuguese Physics Society (DFM_SPF) in collaboration with the IAEA, carried out a national auditing project in radiotherapy, between September 2011 and April 2012. The objective of this audit was to ensure the optimal usage of treatment planning systems. The national results are presented in this paper. MATERIAL AND METHODS: The audit methodology simu...

Síndroma de Williams. Da Clínica à Genética Molecular

O Síndroma de Williams tem uma expressão fenotípica variável, que inclui um fácies característico, atraso do desenvolvimento psicomotor, cardiopatia e outras anomalias, nomeadamente renais ou esqueléticas. Recentemente foi identificada nestes doentes a presença de uma microdelecção de dimensões variáveis no cromossoma 7 (7q11.23), que inclui o gene da elastina. O rastreio desta microdelecção, através da técnica...

Choque Séptico no Recém-Nascido. Experiência da Unidade de Cuidados Intensivos ...

O choque séptico (CS) é uma reacção fisiológica sistémica a uma infecção que constitui um problema das unidades de cuidados intensivos neonatais (UCIN), sendo uma causa frequente de morte nessas unidades.Com o objectivo de determinar a prevalência do choque séptico na UCIN do Hospital de São João, os factores de prognóstico e a mortalidade, os autores apresentam um estudo retrospectivo descritivo dos recém-nasc...

Colestase Neonatal. Uma Realidade em Cuidados Intensivos Neonatais

A hepatite neonatal e a atrésia biliar, foram durante muitos anos responsáveis pela maioria dos casos de colestase em recém-nascidos.Estudos mais recentes demonstram que a sépsis e a nutrição parenteral são actualmente as principais causas.O objectivo deste estudo foi identificar a etiologia, a morbilidade e a mortalidade nos recém-nascidos com colestase internados na nossa unidade.Estudámos 12 recém-nascidos, ...

Ansiedade Social na Infância e Pré-Adolescência: Adaptação para o Português de ...

The Social Anxiety Scale for Children (revised form) - SASC-R evaluates the experience of social anxiety and avoidance felt by children and pre-adolescents in the context of relationship with their peers. This study aims to validate the Portuguese version of the SASC-R by confirmatory factor analysis using the structure proposed by the authors of the original scale. In a survey donewith 486 children between the...