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Poly(D,L-lactic-co-glycolic acid) nanoencapsulation reduces erlotinib-Induced s...
Gregory, Marslin; Sheeba, Caroline J.; Kalaichelvan, V. K.; Manavalan, R.; Reddy, Neelakanta; Gregory, FranklinErlotinib-HCl is a quinazoline derivative used as a drug in the therapy of non-small-cell lung cancer. The present study was conducted to compare the subacute toxicity induced by Erlotinib-HCl delivered to rats as nanoparticles and as free drug. Wistar rats were orally administered with a daily dosage of 200 mg kg−1 Erlotinib-HCl either as free drug or as Poly(D,L-lactic-co-glycolic acid) (PLGA) encapsulated na...
Data: 2009
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Origem: RepositóriUM - Universidade do Minho
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