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SIRT2: in the crossroad of aging, neurodegeneration and autophagy

Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2013 ; Sirtuin 2 (SIRT2) is the most abundant sirtuin in the brain and its relation with neurodegenerative diseases is now being intensively investigated (Maxwell et al., 2011). In particular, pharmacological inhibition of SIRT2 was shown to negatively modulate α-synuclein (aSyn) mediated toxicity (Outeir...