Objective: The aim of this study was to evaluate a formulation made of poly(lactide-co-glycolide) (PLGA) nanoparticles containing azelaic acid for potential acne treatment. Methods: Azelaic acid-loaded PLGA nanoparticles were prepared by spontaneous emulsification processes using poloxamer 188 as stabilizer. Several manufacturing parameters such as stirring rate, concentration of stabilizer and different recov...
Effective formulation for peptide and protein delivery through the oral route has always been the critical effort with the advent of biotechnology. Stability, enzymatic degradation and ineffective absorption are common difficulties found for conventional dosage forms. As a result, new drug-delivery approaches are used to circumvent these limitations and enhance effective oral drug delivery. Some of these techno...
Azelaic acid (AzA) is used in the treatment of acne. However, side effects and low compliance have been associated with several topical treatments with AzA. Nanotechnology presents a strategy that can overcome these problems. Polymeric nanoparticles can control drug release and targeting and reduce local drug toxicity. The aim of this study was to produce and evaluate an innovative topical treatment for acne wi...
O presente trabalho corresponde ao relatório final do Projecto POCI/AGR/59180/2004 “Avaliação do Impacte de Fogos Florestais nos Recursos Hídricos Subterrâneos” e nele se avalia o impacto dos fogos no meio hídrico superficial e subterrâneo, considerando as alterações quantitativas no meio hídrico – escoamento superficial, recarga, evapotranspiração – e de qualidade. Na avaliação da alteração da qualidade das ág...
O relatório apresenta os trabalhos desenvolvidos no âmbito do Projeto POCI/AGR/59180/2004 entre 1 de janeiro e 31 de dezembro de 2007. O relatório organiza-se pela descrição das seguintes tarefas: T1 – Selecção das áreas de estudo; T2 – Caracterização agro-florestal; T3 – Caracterização de cinzas e testes laboratoriais de combustão; T4 – Modelação do ciclo hidrológico e caracterização da qualidade da água; T5 –...
Este estudo tem como objectivo a aplicação de uma metodologia para a delimitação da REN do concelho de Nisa, baseada em Sistemas de Informação Geográfica (SIG) e sua comparação com a REN legalmente aprovada.
The growing interest in the study of natural convection in geometrically complex enclosures with restricted communication has been stimulated by applications involving energy-efficient passive-solar buildings, natural convection cooling of electronic equipment and room heating and ventilation. Airflow through doorways, windows and other large openings are significant ways in which air, pollutants and thermal en...
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