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Investigation of different hydrogels for nucleus replacement : a biomechanical ...
Reitmaier, Sandra; Wolfram, Uwe; Ignatius, Anita; Wilke, Hans-Joachim; Martín-Martínez, José M.; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.Hydrogels are considered promising for disc regeneration strategies. However, it is currently unknown whether the destruction of the natural interface between nucleus and surrounding structures caused by nucleotomy and an inadequate annulus closure diminishes the mechanical competence of the disc. To clarify these mechanisms and to evaluate whether hydrogels are able to restore the biomechanical behaviour of th...
Hydrogels for nucleus replacement : facing a biomechanical challenge
Reitmaier, S.; Wolfram, U.; Ignatius, A.; Wilke, H. - J.; Gloria, A.; Martín-Martínez, José M.; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.Hydrogelsareconsideredpromisingfordiscregenerationstrategies.However,itiscurrently unknownwhetherthedestructionofthenaturalinterfacebetweennucleusandsurrounding structurescausedbynucleotomyandaninadequateannulusclosurediminishesthemechan- ical competenceofthedisc.This in vitro studyaimedtoclarifythesemechanismsandto evaluatewhetherhydrogelsareabletorestorethebiomechanicalbehaviourofthedisc. Nucleuspressureinano...
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