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Increased breast cancer cell toxicity by palladination of the polyamine analogu...
Silva, Tânia M.; Fiuza, Sonia M.; Marques, Maria P. M.; Lo, Persson; Oredsson, StinaBreast cancer is one of the most common malignant tumor forms among women and many women succumb to their disease. Thus, new anticancer agents that can efficiently improve patient survival are of the utmost importance. In this study, the effects of the polyamine analogues N1,N11-bis(ethyl)norspermine (BENSpm) and N1-cyclo-propylmethyl-N11-ethylnorspermine (CPENSpm) and the synthesized dinuclear complexes Pd2BEN...
Structural Studies on Supramolecular Adducts of Cyclodextrins with the Complex ...
Marques, Joana; Anjo, Lucia; Marques, Maria P. M.; Santos, Teresa M.; Paz, Filipe A. Almeida; Braga, Susana S.http://www.sciencedirect.com/science/article/B6TGW-4SV5VBS-B/1/da1bbc59614cc3a26a3bdce77219c7c9
Antioxidant Versus Cytotoxic Properties of Hydroxycinnamic Acid Derivatives - A...
Esteves, Mário; Siquet, Christophe; Gaspar, Alexandra; Rio, Vitor; Sousa, Joana B.; Reis, Salette; Marques, Maria P. M.; Borges, FernandaTrihydroxycinnamic derivatives were synthesized and evaluated for their antioxidant and cytotoxic activities. The ester derivatives exhibited a higher radical-scavenging activity, when liposomes were used as target systems, a fact which may be related to their lipophilicity and conformational preferences. These compounds were found to display significant growth inhibition and cytotoxic effects towards a human c...
Use of Effective Core Potential Calculations for the Conformational and Vibrati...
Fiuza, Sónia M.; Amado, Ana M.; Marques, Maria P. M.; Carvalho, Luis A. E. Batista deIn the light of the recognized anticancer properties of cisplatin-type inorganic systems, the exact knowledge of their conformational preferences is of the utmost importance for understanding their biological activity. The present study reports the use of theoretical (quantum mechanical) calculations for achieving this goal. An alternative calculation method to the use of the AE basis sets, both accurate and co...
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