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Monitoring Abacavir Bioactivation in Humans: Screening for an Aldehyde Metabolite
Grilo, N; Antunes, A; Caixas, U; Marinho, A; Charneira, C; Oliveira, MC; Monteiro, E; Marques, MM; Pereira, SThe anti-HIV drug abacavir is associated with idiosyncratic hypersensitivity reactions and cardiotoxicity. Although the mechanism underlying abacavir-toxicity is not fully understood, drug bioactivation to reactive metabolites may be involved. This work was aimed at identifying abacavir-protein adducts in the hemoglobin of HIV patients as biomarkers of abacavir bioactivation and protein modification. The protoc...
Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidam...
Bandarra, S; Fernandes, AS; Magro, I; Guerreiro, PS; Pingarilho, M; Churchwell, MI; Gil, OM; Batinic-Haberle, I; Gonçalves, S; Rueff, J; Miranda, JPAcrylamide (AA) is a well-known industrial chemical classified as a probable human carcinogen. Benign and malignant tumours at different sites, including the mammary gland, have been reported in rodents exposed to AA. This xenobiotic is also formed in many carbohydrate-rich foods prepared at high temperatures. For this reason, AA is an issue of concern in terms of human cancer risk. The epoxide glycidamide (GA)...
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