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Electrochemical oxidation of mitoxantrone at a glassy carbon electrode
Brett, A. M. Oliveira; Macedo, T. R. A.; Raimundo, D.; Marques, M. H.; Serrano, S. H. P.Mitoxantrone is an anthracycline used as an antitumour antibiotic for leukaemia and breast cancer treatment, due to its interaction with DNA. However, the molecular mechanism of the antitumour action is not completely understood. Using a glassy carbon electrode the electrochemical oxidation of mitoxantrone was shown to be a complex, pH-dependent, irreversible electrode process involving several metabolites. Com...
Voltammetric behaviour of mitoxantrone at a DNA-biosensor
Brett, A. M. Oliveira; Macedo, T. R. A.; Raimundo, D.; Marques, M. H.; Serrano, S. H. P.The surface of an electrochemical glassy carbon electrode was modified with a layer of double-stranded DNA (dsDNA) or with double-stranded DNA conditioned in single-stranded DNA (ssDNA) and was used to investigate mitoxantrone-DNA interactions. Differential pulse and square wave voltammetry were applied to develop an electroanalytical procedure for the determination of mitoxantrone and evaluate its interaction ...
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