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An inelastic neutron scattering study of dietary phenolic acids
Marques, M. P. M.; Batista de Carvalho, Luís A. E.; Valero, Rosendo; Machado, Nelson F. L.; Parker, Stewart F.The conformational preferences and hydrogen-bonding motifs of several potential chemopreventive hydroxycinnamic derivatives were determined by inelastic neutron scattering spectroscopy. The aim is to understand their recognized beneficial activity and establish reliable structure–activity relationships for these types of dietary phytochemicals. A series of phenolic acids with different hydroxyl/methoxyl ring su...
The current role of surgery in the treatment of gastroduodenal ulcer
Gomes, Aline; Interna do 6º ano de Cirurgia Geral; Serviço de Cirurgia 1 do Centro Hospitalar de Tondela Viseu, PortugalSurgery for gastroduodenal ulcer disease has been declining in the past few decades and the role of surgery in the treatment of gastroduodenal ulcer has been referred to the treatment of this complications. In this paper, the authors proposed to study the current role of surgery in the treatment of this disease between January 2001 and December 2010. During this period 134 patients were operated, all for compli...
Hydrodynamic profile of young swimmers: changes over a competitive season
Barbosa, Tiago M.; Morais, J.E.; Marques, M.C.; Silva, A.J.; Marinho, D.A.; Kee, Y.H.The aim of this study was to analyze the changes in the hydrodynamic profile of young swimmers over a competitive season and to compare the variations according to a well-designed training periodization. Twenty-five swimmers (13 boys and 12 girls) were evaluated in (a) October (M1); (b) March (M2); and (c) June (M3). Inertial and anthropometrical measures included body mass, swimmer’s added water mass, height, an...
Síndroma de Williams. Da Clínica à Genética Molecular
J. D, Ferreira Martins; A., Medeira; I., Cordeiro; B., Marques; M. G., Boavida; H. G., SantosO Síndroma de Williams tem uma expressão fenotípica variável, que inclui um fácies característico, atraso do desenvolvimento psicomotor, cardiopatia e outras anomalias, nomeadamente renais ou esqueléticas. Recentemente foi identificada nestes doentes a presença de uma microdelecção de dimensões variáveis no cromossoma 7 (7q11.23), que inclui o gene da elastina. O rastreio desta microdelecção, através da técnica...
Hipotonia Esclarecida com um Aperto de Mão. Doença de Steinert
Marques, M. Eduarda; Antunes, Henedina; Reis, Helena CunhaOs AAs apresentam o caso clínico de uma criança de 4 anos seguida no Hospital de São Marcos por Doença de Steinert lá diagnosticada aos 4meses. Apresentava hipotonia generalizada com diminuição dos reflexos osteotendinosos, hipotrofia dos músculos temporais, pseudodiplegia da face,lábio superior em acento circunflexo, dificuldade em deglutir, choro fraco, sopro cardíaco e pés botos.A mãe tinha baixa estatura, v...
Transplant glomerulopathy: clinico-pathologic features
Silva, C; Cotovio, P; Marques, M; Afonso, N; Sancho, MR; Carvalho, F; Trindade, H; Carreira, A; Campos, M; Nolasco, FTransplant glomerulopathy is a sign of chronic kidney allograft damage. It has a distinct morphology and is associated with poor allograft survival. We aimed to assess the prevalence and clinic-pathologic features of transplant glomerulopathy, as well as determine the functional and histological implications of its severity. We performed a single-centre retrospective observational study during an eight-year per...
A conformational study of hydroxylated isoflavones by vibrational spectroscopy ...
Machado, N. F. L.; Batista de Carvalho, L. A. E.; Otero, J. C.; Marques, M. P. M.The conformational preferences of a series of hydroxylated isoflavones were studied by optical vibrational spectroscopy (FTIR and Raman) coupled with density functional theory (DFT) calculations. Special attention was paid to the effect of the hydroxyl substitution, due to the importance of this group in the biological activity of these systems. The isoflavones investigated – daidzein, genistein and formononeti...
New sustained release of Zidovudine Matrix tablets − cytotoxicity toward Caco-2...
Santos, Jucimary V.; Pina, Maria Eugénia T.; Marques, M. P. M.; Batista de Carvalho, Luís A. E.Objective: The aim of this study was to adjust the zidovudine (AZT) release from solid tablets to an ideal profile, by developing matrices comprising swellable polymers with nonswellable ones. Methods: Directly compressed matrices comprised different ratios of hydroxypropylmethylcellulose K15M and K100M, ethylcellulose, and methacrylic acid (Eudragit® RS PO and Eudragit® RL PO) were prepared. Technological char...
Applying vibrational spectroscopy to the study of nucleobases – adenine as a ca...
Lopes, Rui P.; Valero, Rosendo; Tomkinson, John; Marques, M. P. M.; Batista de Carvalho, Luís A. E.A full conformational study of solid-state anhydrous adenine is reported, using vibrational spectroscopy techniques coupled to DFT calculations, for the isolated molecule and the solid. In both cases, the N9Hamino tautomer was found to be the predominant species, followed by the N7H-amino form. An excellent agreement was achieved between experiment and theory, both for wavenumbers and intensities (without the n...
Transplant Glomerulopathy: Clinico-Pathologic Features
Silva, C; Cotovio, P; Marques, M; Afonso, N; Sancho, MR; Carvalho, F; Trindade, H; Carreira, A; Campos, M; Nolasco, FTransplant glomerulopathy is a sign of chronic kidney allograft damage. It has a distinct morphology and is associated with poor allograft survival. We aimed to assess the prevalence and clinic-pathologic features of transplant glomerulopathy, as well as determine the functional and histological implications of its severity. We performed a single-centre retrospective observational study during an eight-year per...
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