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Retrospective analysis of clinical yeast isolates in a hospital in the centre o...
Paulo, Cristiana; Mourão, Cristina; Veiga, Pedro M.; Marques, Joana M.; Rocha, Graça; Alves, Ana F.; Querol, Amparo; Meliço-Silvestre, António A.We conducted a four-year (2003-2006) retrospective study of yeasts recovered in a hospital laboratory in the centre of Portugal to evaluate the epidemiology of yeast infections. Clinical isolates and data were gathered from 751 patients corresponding to 906 episodes of yeast infection. The isolates were first identified using classical and commercial methods, routinely employed at the hospital laboratory. We th...
Saccharomyces cerevisiae Hog1 protein phosphorylation upon exposure to bacteria...
Marques, Joana M.; Rodrigues, Ricardo J.; Sant'Ana, Augusto C. de Magalhães; Gonçalves, TeresaThe yeast Hog1 protein is both functionally and structurally similar to the mammalian p38, belonging to the same family of mitogen-activated protein (MAP) kinases and responding to extracellular changes in osmolarity. Since p38 mediates lipopolysaccharide (LPS) effects in mammalian cells, we now tested the responsiveness of Hog1 upon exposure of the yeast Saccharomyces cerevisiae to bacterial LPS. In the presen...
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