Encontrados 5 documentos, a visualizar página 1 de 1
Topographical analysis of the subependymal zone neurogenic niche
Falcão, Ana M.; Palha, Joana Almeida; Ferreira, Ana Catarina; Marques, Fernanda Cristina Gomes de Sousa; Sousa, Nuno; Sousa, João CarlosThe emerging model for the adult subependymal zone (SEZ) cell population indicates that neuronal diversity is not generated from a uniform pool of stem cells but rather from diverse and spatially confined stem cell populations. Hence, when analysing SEZ proliferation, the topography along the anterior-posterior and dorsal-ventral axes must be taken into account. However, to date, no studies have assessed SEZ pr...
Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevan...
Palha, Joana Almeida; Santos, Nadine Correia; Marques, Fernanda Cristina Gomes de Sousa; Sousa, João; Bessa, João; Miguelote, Rui; Sousa, NunoSchizophrenia is a neurodevelopment disorder in which the interplay of genes and environment contributes to disease onset and establishment. The most consistent pathological feature in schizophrenic patients is an enlargement of the brain ventricles. Yet, so far, no study has related this finding with dysfunction of the choroid plexus (CP), the epithelial cell monolayer located within the brain ventricles that ...
Transcriptome signature of the adult mouse choroid plexus
Marques, Fernanda Cristina Gomes de Sousa; Sousa, João Carlos; Coppola, Giovanni; Gao, Fuying; Puga, Renato; Brentani, Helena; Geschwind, Daniel H.Background: Although the gene expression profile of several tissues in humans and in rodent animal models has been explored, analysis of the complete choroid plexus (CP) transcriptome is still lacking. A better characterization of the CP transcriptome can provide key insights into its functions as one of the barriers that separate the brain from the periphery and in the production of cerebrospinal fluid. Method...
In vivo biodistribution of carboxymethylchitosan/poly(amidoamine) dendrimer nan...
Pereira, Vitor H.; Salgado, A. J.; Oliveira, Joaquim M.; Cerqueira, Susana R.; Frias, A. M.; Fraga, J. S.; Roque, Susana; Falcão, Ana M.Carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles (CMCht/PAMAM) have recently been proposed for intracellular drug delivery purposes. These are constituted by a PAMAM dendrimer core grafted with chains of CMCht. Previous reports have shown that these nanoparticles disclosed an improved cytotoxic profile when compared to traditional dendrimers. Following on these results the present study aims to as...
The choroid plexus as a sensor of peripheral inflammation
Marques, Fernanda Cristina Gomes de SousaTese de Doutoramento Ciências da Saúde - Ciências Biológicas e Biomédicas ; Particular interest has been raised in the last few years, regarding the contribution of the immune system in neurological and psychiatric diseases. It is recognized that an inflammatory component underlies disorders such as Alzheimer’s disease and multiple sclerosis. However, whether these are a consequence, a cause, or just a trigger...
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