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Longevity pathways and maintenance of the proteome : the role of autophagy and ...
Marques, Belém Sampaio; Ludovico, Paula; Burhans, William C.Ageing is a complex and multi-factorial process that results in the progressive accumulation of molecular alterations that disrupt different cellular functions. The budding yeast Saccharomyces cerevisiae is an important model organism that has significantly contributed to the identification of conserved molecular and cellular determinants of ageing. The nutrient-sensing pathways are well-recognized modulators o...
Involvement of yeast HSP90 isoforms in response to stress and cell death induce...
Silva, Maria Alexandra; Marques, Belém Sampaio; Fernandes, Ângela Margarida Oliveira; Carreto, Laura; Rodrigues, Fernando José dos SantosAcetic acid-induced apoptosis in yeast is accompanied by an impairment of the general protein synthesis machinery, yet paradoxically also by the up-regulation of the two isoforms of the heat shock protein 90 (HSP90) chaperone family, Hsc82p and Hsp82p. Herein, we show that impairment of cap-dependent translation initiation induced by acetic acid is caused by the phosphorylation and inactivation of eIF2 alpha by...
An alternative respiratory pathway on Candida krusei : implications on suscepti...
Oliveira, Sofia Costa de; Marques, Belém Sampaio; Barbosa, Matilde; Ricardo, Elisabete; Vaz, Cidália Pina; Ludovico, Paula; Rodrigues, Acácio G.Our aim was to detect the presence of an alternative oxidase (AOX) in Candida krusei clinical strains and its influence on fluconazole susceptibility and in reactive oxygen species (ROS) production. Candida krusei clinical isolates were tested to evaluate the presence of AOX. Debaromyces hansenii 2968 (AOX positive) and Saccharomyces cerevisiae BY4742 (AOX negative) were used as control strains. Measurements of...
The emerging role of autophagy - mitophagy in α-synuclein-induced toxicity : st...
Marques, Belém SampaioTese de doutoramento em Ciências da Saúde ; α-Synuclein (α-syn) misfolding and aggregation is strongly associated with both idiopathic and familial forms of Parkinson disease (PD). Evidence suggests that α-syn has an impact on cell clearance routes and protein quality control systems, such as the ubiquitin-proteasome system (UPS) and autophagy. Recent advances in the key role of the autosomal recessive PARK2/P...
Evaluation of the protective effect of Hypericum perforatum phenolics compounds...
Vieira, Pedro Miguel de Sousa; Marques, Belém Sampaio; Ludovico, Paula; Dias, Alberto Carlos PiresParkinson’s disease (PD), first described by James Parkinson in 1817, is a chronic, progressive neurodegenerative disorder. The pathologic hallmark is a deterioration of the substantia nigra of yet unknown causes, resulting in a deficiency of dopamine, an important neurotransmitter for the basal ganglia circuit and the presence of cytoplasmic eosinophilic inclusions named Lewy ...
Hypericum perforatum phenolics compounds : protective role in the toxicity indu...
Vieira, Pedro Miguel de Sousa; Marques, Belém Sampaio; Ludovico, Paula; Dias, Alberto Carlos PiresParkinson’s disease (PD) is a neurodegenerative disorder with high prevalence and is characterized by the loss of dopaminergic neurons and the presence of cytoplasmic eosinophilic inclusions named Lewy bodies, in which α-synuclein is the major constituent. Several studies implicate abnormal protein accumulation, protein phosphorylation, mitochondrial dysfu...
Caloric restriction or catalase inactivation extends yeast chronological lifesp...
Mesquita, Ana Maria Macedo; Weinberger, Martin; Silva, Alexandra; Marques, Belém Sampaio; Almeida, Bruno; Leão, Cecília; Costa, VitorThe free radical theory of aging posits oxidative damage to macromolecules as a primary determinant of lifespan. Recent studies challenge this theory by demonstrating that in some cases, longevity is enhanced by inactivation of oxidative stress defenses or is correlated with increased, rather than decreased reactive oxygen species and oxidative damage. Here we show that, in Saccharomyces cerevisiae, caloric res...
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