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Growth signaling promotes chronological aging in budding yeast by inducing supe...
Weinberger, Martin; Mesquita, Ana Maria Macedo; Carroll, Timothy; Marks, Laura; Hui Yang; Zhaojie Zhang; Ludovico, Paula; Burhans, William CInhibition of growth signaling pathways protects against aging and age-related diseases in parallel with reduced oxidative stress. The relationships between growth signaling, oxidative stress and aging remain unclear. Here we report that in Saccharomyces cerevisiae, alterations in growth signaling pathways impact levels of superoxide anions that promote chronological aging and inhibit growth arrest of stationar...
Data: 2010
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Origem: RepositóriUM - Universidade do Minho
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