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Synthesis and antileishmanial activity of new 1-aryl-1H-pyrazole-4-carboximidam...

Chemotherapy for leishmaniasis, diseases caused by protozoa of the genus Leishmania, remains inefficient in several treatments. So there is a need to search for new drugs. In this work, we have synthesized 1-aryl-1H-pyrazole-4-carboximidamides derivatives and evaluated antileishmanial activities in vitro, as well as cytotoxic effects. Structure-activity relationship (SAR) studies were carried out with all the c...

Neurological diagnoses in the emergency room: differences between younger and o...

Neurological diseases are prevalent in the emergency room (ER). The aim of this study was to compare the neurological diagnoses between younger and older patients evaluated in the ER of a tertiary care hospital. METHOD: Patients admitted to the ER who required neurological evaluation in the first 24 hours were separated into two groups based on age, <;50 years old and &gt;50 years old. RESULTS: Cerebrovascular ...

Tarifa binômia para o custo de água pressurizada em perímetros irrigados

Nos distritos de irrigação, a tarifa de custo variável tem dependido exclusivamente da quantidade de água consumida e não, da energia e da demanda de potência elétrica para o fornecimento de água na pressão e na vazão recomendadas pelo sistema de irrigação. Essa forma de tarifação da água de irrigação é um contrassenso em que os irrigantes mais eficientes subsidiam os irrigantes menos eficientes. Este trabalho ...

Dimensionamento de motores para o bombeamento de água

O dimensionamento de motores com potência acima da necessária acarreta maior custo inicial, menor rendimento e menor fator de potência. Desde 1996, que se fabricam no Brasil motores elétricos com fator de serviço maior do que a unidade, obedecendo a valores prescritos em norma. O fator de serviço informa a potência disponível do motor em regime contínuo para as condições de carga nominal. A literatura técnica d...

Flavonoides e outras substâncias de Lippia sidoides e suas atividades antioxida...

The chemical investigation of the ethanol extracts of stems, roots and leaves of Lippia sidoides led to the isolation of: steroid &#946;-sitosterol, naphthoquinone tecomaquinone, monoterpene carvacrol, flavonoid 4',5,7-trihydroxyflavanone (naringenin), 3',4',5,7-tetrahydroxyflavanone and 4',5,7-trihydroxy-6-methoxyflavone flavonoids mixture, and 3,4,4',6'-tetrahydroxydihydrochalcone-2'-O-&#946;-D-glucopyranosid...

Experimental and theoretical study of the kinetics of dissociation in cis-[RuCl...

The substitution reactions [RuCl2(P-P)(N-N)] + L &#8594; [RuCl(L)(P-P)(N-N)]+ + Cl-, where P-P = 1,4-bis(diphenylphosphino)butane and N-N = 2,2´-bipyridine, 4,4´-dimethoxy-2,2´-bipyridine, 4,4´-dimethylpyridine-2,2´-bipyridine and 4,4´-dichloro-2,2´-bipyridine, L = pyridine (py) or 4-methylpyridine (4-pic), were studied under pseudo-first order conditions. The reactions proceeded by means of a dissociative mech...

Ischemic stroke in a patient with Crohn's disease: a confirmed paradoxical embo...

Bombas de Efluxo em Pseudomonas Aeruginosa. Importância Clínica na Terapêutica

As infecções severas causadas por Pseudomonas Aeruginosa têm assumido na última década um papel de destaque, dado tratar-se de um microrganismo de difícil erradicação e com elevada resistência intrínseca e adquirida. Em P. aeruginosa foram caracterizados sete sistemas de bombas de efluxo, os quais contribuem para o desenvolvimento de fenótipos de multiresistência às classes de antibióticos clinicamente mais rel...

Pulsed-field gel electrophoresis, virulence determinants and antimicrobial susc...

Group B streptococci (GBS) infections occur worldwide. Although serotyping has been used for epidemiologic purposes, this does not accurately characterize enough members of a genetically heterogeneous bacterial population. The aims of this work were to evaluate the genetic diversity of 45 type Ia GBS strains isolated in Brazil by pulsed-field gel electrophoresis as well as to evaluate antimicrobial susceptibili...

Constituents and antioxidant activity of two varieties of coconut water (Cocos ...

An analysis of the constituents of coconut (Cocos nucifera L.) water from two fruit varieties (green and yellow) by hydrodistillation and solvent extraction showed the presence of alcohols, ketones, thiols, carboxylic acids, phenols, and esters. Substantial antioxidant activity was observed, using the DPPH assay, for the samples obtained by hydrodistillation and petroleum ether extraction of both coconut variet...