Encontrados 4 documentos, a visualizar página 1 de 1
Evolution of the human immunodeficiency virus type 2 envelope in the first year...
Rocha, Cheila; Calado, Rita; Borrego, Pedro; Marcelino, José Maria; Bártolo, Inês; Rosado, Lino; Cavaco-Silva, Patrícia; Perpétua, Gomes"Background: Differently from HIV-1, HIV-2 disease progression usually takes decades without antiretroviral therapy and the majority of HIV-2 infected individuals survive as elite controllers with normal CD4+ T cell counts and low or undetectable plasma viral load. Neutralizing antibodies (Nabs) are thought to play a central role in HIV-2 evolution and pathogenesis. However, the dynamic of the Nab response and ...
Resistance to antibody neutralization in HIV-2 infection occurs in late stage d...
Marcelino, José Maria; Borrego, Pedro; Nilsson, Charlotta; Família, Carlos; Barroso, Helena; Maltez, Fernando; Doroana, Manuela; Antunes, FranciscoObjectives: To characterize the nature and dynamics of the neutralizing antibody (NAb) response and escape in chronically HIV-2 infected patients. ; Methods: Twenty-eight chronically infected adults were studied over a period of 1-4 years. The neutralizing activity of plasma IgG antibodies against autologous and heterologous primary isolates was analyzed using a standard assay in TZM-bl cells. Coreceptor usage...
Resposta humoral na infecção por VIH-2 : impacto no diagnóstico, prevenção e ev...
Marcelino, José Maria, 1959-Tese de doutoramento, Ciências Biomédicas (Ciências Biopatalógicas), Universidade de Lisboa, Faculdade de Medicina, 2011 ; Os indivíduos infectados pelo VIH-2 progridem mais lentamente do que os infectados pelo VIH-1, e estima-se que mais de 95% dos indivíduos infectados por VIH-2 estejam incluídos na definição clínica de long-term nonprogressors. Esta diferença faz do VIH-2 um potencial modelo de estudo de um...
Evolutionary and Structural Features of the C2, V3 and C3 Envelope Regions Unde...
Barroso, Helena; Borrego, Pedro; Bártolo, Inês; Marcelino, José Maria; Família, Carlos; Quintas, Alexandre; Taveira, NunoBackground: Unlike in HIV-1 infection, the majority of HIV-2 patients produce broadly reactive neutralizing antibodies, control viral replication and survive as elite controllers. The identification of the molecular, structural and evolutionary footprints underlying these very distinct immunological and clinical outcomes may lead to the development of new strategies for the prevention and treatment of HIV infec...
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