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MAST/Orbit has a role in microtubule-kinetochore attachment and is essential fo...
Maiato, Helder; Sampaio, Paula; Lemos, Catarina L.; Findlay, John; Mar, Carmena; Earnshaw, William C.; Sunkel, Claudio E.Multiple asters (MAST)/Orbit is a member of a new family of nonmotor microtubule-associated proteins that has been previously shown to be required for the organization of the mitotic spindle. Here we provide evidence that MAST/Orbit is required for functional kinetochore attachment, chromosome congression, and the maintenance of spindle bipolarity. In vivo analysis of Drosophila mast mutant embryos undergoing e...
Data: 2002
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Origem: Repositório Aberto da Universidade do Porto
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