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Risco Cardiovascular em Doentes com Infecção por Vírus da Imunodeficiência Humana
Raimundo, P; Miranda, A; Ribeiro, J; Mansinho, KO aumento do risco cardiovascular é considerada uma importante complicação da infecção Infecção por Vírus da Imunodeficiência Humana (VIH) e da terapêutica anti-retroviral (TARV). À disfunção endotelial característica do processo inflamatório crónico desencadeado pela infecção retroviral, associa-se a disfunção metabólica induzida pela terapêutica, predispondo, em conjunto, para a aterogénese precoce. O reconhe...
Coreceptor Usage by HIV-1 and HIV-2 Primary Isolates: The Relevance of CCR8 Che...
Calado, M; Matoso, P; Santos-Costa, Q; Espirito-Santo, M; Machado, J; Rosado, L; Antunes, K; Mansinho, K; Lopes, MM; Maltez, F; Santos-Ferreira, MOThe human immunodeficiency virus replication cycle begins by sequential interactions between viral envelope glycoproteins with CD4 molecule and a member of the seven-transmembrane, G-protein-coupled, receptors' family (coreceptor). In this report we focused on the contribution of CCR8 as alternative coreceptor for HIV-1 and HIV-2 isolates. We found that this coreceptor was efficiently used not only by HIV-2 but...
Normas de Actuação após Exposição Acidental a Produtos Biológicos Potencialment...
Borges, A; Guerreiro, C; Paredes, P; Nabais, H; Mansinho, KOs autores apresentam as normas de actuação pós-exposição acidental a produtos biológicos (sangue ou fluídos) potencialmente infectados (com destaque para o VIH, AgHbS e VHC). No caso concreto de exposição ao VIH, a decisão para a recomendação da profilaxia pós-exposição deve ser tomada tendo em conta a natureza da exposição (ex: agulhas ou fluídos potencialmente infectados, em contacto com as mucosas) bem como...
Immunologic profile of HIV-2 seropositive African individuals (follow-up).
Pinto, A S; Instituto de Higiene e Medicina Tropical, Laboratório de Imunologia, I.P.O.F.G., Lisboa.; Ferreira, W F; Costa, C; Silva, A P; Alvarez, E PIn the geographic distribution of HIV-2, it is known that this infection is most prevalent in West Africa. Since 1986 we have studied seropositive and seronegative clusters, in Guinea-Bissau with follow-ups in 1988, 1989, 1990 and 1991. Analysis of the results show the high incidence of this infection. 8.51% of the 4,372 people of the general population studied were seropositive, showing the high predominance o...
Human immunodeficiency virus type 2 infection.
Mansinho, K; Serviço de Doenças Infecciosas, Hospital Egas Moniz, Lisboa.The isolation of a second retrovirus, HIV-2, led to fears that a second AIDS pandemic, similar in scope and magnitude to that caused by HIV-1, might ensue. However, the peculiar biologic properties of HIV-2, namely the lower transmissibility of this virus through both sexual and vertical routes, contributed to a more regionalized distribution of the virus, which became endemic in West Africa. HIV-2 is genetical...
Verrucous herpes zoster in AIDS patients.
Agusto, V; Unidade de Doenças Infecciosas e Parasitárias, Hospital Egaz Moniz.; Franca, I; Mansinho, K; Araújo, C; Borges, F; Champalimaud, J LThe authors describe a case of disseminated Herpes-Zoster (VZV) in an HIV 1 positive patient with AIDS. Hyperkeratotic characteristics, acyclovir resistance and sensitivity to foscarnet of cutaneous lesions are the most important features of this example. From the casuistics of the department, the authors describe two similar cases and review the medical literature with emphasis on etiopathogenic, diagnostic an...
Cutaneous infection with the cytomegalovirus virus in AIDS patients.
Franca, I; Unidade de Doenças Infecciosas e Parasitárias, Hospital Egas Moniz/Instituto de Higiene e Medicina Tropical, Lisboa.; Poiares-Baptista, ACutaneous cytomegalovirus (CMV) infection has been observed in a variety of nonspecific skin lesions. Because of this fact, its diagnosis is rare and frequently accidental. The presence of the virus has also been observed in apparently normal skin, from both a clinical and histological point of view. In this context, skin biopsy and immunohistochemistry are often the first means of diagnosis of systemic CMV inf...
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