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Recomendações para Análise Mutacional em Tumores do Estroma Gastrointestinal (G...
Lopes, JM; Soares, M; Gouveia, AM; Barroso, S; Cravo, M; Mansinho, H; Penedo, J; Sá, A; Santos, LL; Teixeira, JAOs autores apresentam as recomendações para a análise mutacional de GISTs, aprovadas por unanimidade por um grupo multidisciplinar em 20 de Julho de 2012. O estado mutacional de genes como o KIT e o PDGFRA permite identificar alvos terapêuticos para inibidores da tirosinacínase (ITKs) e, por isso, a boa prática clínica nas decisões bioterapêuticas de doentes com GISTs deve incluir a análise do estado mutacional...
Recommendations for Mutational Analysis in Gastrointestinal Stromal Tumors (GIS...
Lopes, J M; Faculdade de Medicina do Porto, Serviço de Anatomia Patológica do Centro Hospitalar de S.João, e IPATIMUP, Porto - PortugalGIST Portuguese Working Group – Condeixa ProposalThe authors outline recommendations for the mutational analysis of GISTs unanimously approved by a multidisciplinary group on July 20th, 2062. The mutational status of KIT and PDGFRA allows identifying therapeutic targets to tyrosine kinase inhibitors (TKIs), and therefore, the safe clinical practice in the biotherapy decisions for patients with GISTs should incl...
The rare metastasis of osteosarcoma of a long bone associated with von Reckling...
Ferreira, M M; Centro de Lisboa, Instituto Português de Oncologia Francisco Gentil, Clínica VII.; Mansinho, H; Fernandes, A; Pereira, F SWe report a case of femoral osteosarcoma with brain metastases in a female patient with longstanding von Recklinghausen disease. Osteosarcoma of a long bone has not yet, to our best knowledge, been reported in association with type I Neurofibromatosis. Central nervous system metastases occur very rarely in osteosarcoma. ; We report a case of femoral osteosarcoma with brain metastases in a female patient with l...
Clear cell hepatocellular carcinoma.
Mansinho, H; Clínica VII, Instituto Português de Oncologia Francisco Gentil, Lisboa.; Ferreira, M; Fernandes, A; Chaves, P; Assis e Santos, .A case of a 62 year old white patient with mild dyspeptic symptoms and nodular hepatomegaly is presented. The histologic examination of a liver biopsy revealed a hepatocellular carcinoma clear cell variant. There were no signs of chronic hepatic failure. The disease showed an indolent clinical behaviour, thus the beginning of chemotherapy was delayed until clinical deterioration was obvious. Clinical improvemen...
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