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Effects of starch/polycaprolactone-based blends for spinal cord injury regenera...
Salgado, A. J.; Sousa, R. A.; Fraga, J. S.; Pêgo, José M.; Silva, B. A.; Malva, J. O.; Neves, N. M.; Reis, R. L.; Sousa, NunoSpinal cord injury (SCI) leads to drastic alterations on the quality of life of afflicted individuals. With the advent of Tissue Engineering and Regenerative Medicine where approaches combining biomaterials, cells and growth factors are used, one can envisage novel strategies that can adequately tackle this problem. The objective of this study was to evaluate a blend of starch with poly(ε-caprolactone) (SPCL) a...
Neuropeptide Y can rescue neurons from cell death following the application of ...
Xapelli, S.; Silva, A. P.; Ferreira, R.; Malva, J. O.In the present work we investigated the neuroprotective role of neuropeptide Y (NPY) after an excitotoxic insult in rat organotypic hippocampal slice cultures. Exposure of 2 week-old rat hippocampal slice cultures to 12 [mu]M kainate (KA) for 24 h induced neuronal death in dentate gyrus (DG) granular cell layer, CA1 and CA3 pyramidal cell layers, as quantified by cellular propidium iodide (PI) uptake. The activ...
Modulation of dopamine and noradrenaline release and of intracellular Ca2+ conc...
Malva, J. O.; Carvalho, A. P.; Carvalho, C. M.1. We studied the release of [3H]-dopamine and [3H]-noradrenaline (NA) from hippocampal synaptosomes induced by glutamate receptors and the associated Ca2+ influx through Ca2+ channels. The release of tritiated neurotransmitters was studied by use of superfusion system and the intracellular free Ca2+ concentration ([Ca2+]i) was determined by a fluorimetric assay with Indo-1 as a probe for Ca2+. 2. Presynaptic g...
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