Encontrados 2 documentos, a visualizar página 1 de 1
In silico versus in vitro analysis of LDLR mutations
Alves, A.C.; Silva, S.; Patel, D.; Malhó, R.; Soutar, A.K.; Bourbon, M.The LDL receptor (LDLR) is a glycoprotein that mediates binding and internalization of cholesterol-rich lipoproteins from plasma. Mutations in the LDLR gene are the major cause of familial hypercholesterolaemia (FH), which results in impaired catabolism of circulating LDL. This common autosomal inherited metabolism disorder leads to premature atherosclerosis and increased risk of CHD. Many different mutations (...
Signalling pathways in pollen germination and tube growth
Malhó, R.; Liu, Q.; Monteiro, D.; Rato, C.; Camacho, L.; Dinis, A.Summary. Signalling is an integral component in the establishment and maintenance of cellular identity. In plants, tip-growing cells represent an ideal system to investigate signal transduction mechanisms, and among these, pollen tubes (PTs) are one of the favourite models. Many signalling pathways have been identified during germination and tip growth, namely, Ca2+, calmodulin, phosphoinositides, protein kina...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||