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Transition of Plasmodium Sporozoites into Liver Stage- Like Forms Is Regulated ...
Gomes-Santos, Carina S. S.; Braks, Joanna; Prudêncio, Miguel; Carret, Céline; Gomes, Ana Rita; Pain, Arnab; Feltwell, Theresa; Khan, ShahidMany eukaryotic developmental and cell fate decisions that are effected post-transcriptionally involve RNA binding proteins as regulators of translation of key mRNAs. In malaria parasites (Plasmodium spp.), the development of round, non-motile and replicating exo-erythrocytic liver stage forms from slender, motile and cell-cycle arrested sporozoites is believed to depend on environmental changes experienced dur...
Universal features of post-transcriptional gene regulation are critical for pla...
Mair, Gunnar R.; Lasonder, Edwin; Garver, Lindsey S.; Franke-Fayard, Blandine M. D.; Carret, Céline K.; Wiegant, Joop C. A. G.; Dirks, Roeland W.A universal feature of metazoan sexual development is the generation of oocyte P granules that withhold certain mRNA species from translation to provide coding potential for proteins during early post-fertilization development. Stabilisation of translationally quiescent mRNA pools in female Plasmodium gametocytes depends on the RNA helicase DOZI, but the molecular machinery involved in the silencing of transcri...
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