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Long-term effects of tafamidis for the treatment of transthyretin familial amyl...
Coelho, T.; Maia, L.; Martins-Silva, A.; Cruz, M.; Planté-Bordeneuve, V.; Suhr, O.; Conceição, I.; Schmidt, H.; Trigo, P.; Kelly, J.; Labaudinière, R.Tafamidis, a transthyretin (TTR) kinetic stabilizer, delayed neuropathic progression in patients with Val30Met TTR familial amyloid polyneuropathy (TTR-FAP) in an 18-month randomized controlled trial (study Fx-005). This 12-month, open-label extension study evaluated the long-term safety, tolerability, and efficacy of tafamidis 20 mg once daily in 86 patients who earlier received blinded treatment with tafamidi...
A case of haemophagocytic syndrome presenting with oculogyric crises
Taipa, R.; Moreira, B.; França, M.; Maia, L.Haemophagocytic lymphohistiocytosis (HLH), also called haemophagocytic syndrome (HPS), is a rare disorder resulting in abnormal proliferation of histiocytes in tissues and organs, including the CNS. HLH can present as a primary disease or occur as a secondary reactive disease. Clinical features are high fever, splenomegaly, cytopenia of two or more cell lines, hypertriglyceridaemia and haemophagocytosis. CNS in...
Superficial siderosis: a potential diagnostic marker of cerebral amyloid angiop...
Feldman, H.; Maia, L.; Mackenzie, I.; Forster, B.; Martzke, J.; Woolfenden, A.Abstract BACKGROUND AND PURPOSE: Superficial siderosis of the central nervous system results from chronic bleeding in the superficial layers of the cortex and spinal cord. In cerebral amyloid angiopathy (CAA), there is amyloid deposition in meningeal and meningo-cortical arteries and capillaries, predisposing them to rupture. CAA is frequently associated with Alzheimer disease (AD). METHODS: We report a series...
Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or am...
HIRSCH‐REINSHAGEN, V.; CHAN, J.Y.; WILKINSON, A.; TANAKA, T.; FAN, J.; OU, G.; MAIA, L.F.; SINGARAJA, R.R.; HAYDEN, M.R.; WELLINGTON, C.L.J Lipid Res. 2007 Apr;48(4):914-23. Epub 2007 Jan 18. Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-beta peptide levels in vivo. Hirsch-Reinshagen V, Chan JY, Wilkinson A, Tanaka T, Fan J, Ou G, Maia LF, Singaraja RR, Hayden MR, Wellington CL. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada. Abstract ABCA1-deficient mic...
Clinical phenotypes of Cerebral Amyloid Angiopathy
MAIA, L.; MACKENZIE, IR.; FELDMAN, HH.J Neurol Sci. 2007 Jun 15;257(1-2):23-30. Epub 2007 Mar 6. Clinical phenotypes of Cerebral Amyloid Angiopathy. Maia LF, Mackenzie IR, Feldman HH. Source Department of Neurology, Hospital Geral Santo António, Porto, Portugal. Abstract The term Cerebral Amyloid Angiopathy (CAA) is used to describe the pathological changes occurring in cerebral blood vessels, both leptomeningeal and cortical that result from the d...
Hypersomnia in Whipple disease: case report.
MAIA, L.; MARTA, M.; LOPES, V.; ROCHA, N.; LOPES, C.; MARTINS‐DA‐SILVA, A.; MONTEIRO, L.Arq Neuropsiquiatr. 2006 Sep;64(3B):865-8. Hypersomnia in Whipple disease: case report. Maia LF, Marta M, Lopes V, Rocha N, Lopes C, Martins-da-Silva A, Monteiro L. SourceDepartment of Neurological Disordes and Senses, Hospital Geral de Santo António, Largo Prof. Abel Salazar, 4099-001 Porto, Portugal. Abstract Whipple disease (WD) is a rare systemic infection caused by Tropheryma whippelii. Neurological invol...
The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloi...
HIRSCH‐REINSHAGEN, V.; MAIA, L.F.; BURGESS, B.L.; BLAIN, J.F.; NAUS, K.E.; MCISAAC, S.A.; PARKINSON, P.F.; CHAN, J.Y.; TANSLEY, G.H.; HAYDEN, M.R.J Biol Chem. 2005 Dec 30;280(52):43243-56. Epub 2005 Oct 5. The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease. Hirsch-Reinshagen V, Maia LF, Burgess BL, Blain JF, Naus KE, McIsaac SA, Parkinson PF, Chan JY, Tansley GH, Hayden MR, Poirier J, Van Nostrand W, Wellington CL. Department of Pathology and Laboratory Medicine, Univers...
Avaliação da capacidade dessecante de duas zeolitas obtidas da modificação hidr...
Girão,J. H. S; Maia,L. G. C.; Silva,L. R. D. daAs zeolitas P e phillipsita obtidas previamente, a partir de reações hidrotérmicas em meio alcalino de um caulim vermelho do Ceará, foram submetidas a avaliações quanto à capacidade dessecante aplicadas ao solvente acetato de etila contendo quantidades de água que variam de 0,1 a 1%v/v. Os resultados mostram que ambas zeolitas apresentam boa capacidade dessecante, tendo a phillipsita alcançado um desempenho not...
Effect of scorpion toxin on the enterochromaffin-like cells in normal and Trypa...
Toppa,N. H.; Leite,V. H. R.; Barbosa,A. J. A.; Chiari,E.; Gonzaga,H. M. S.; Freire-Maia,L.; Cunha-Melo,J. R.Intravenous injection of scorpion toxin (Tityus serrulatus) in normal and Trypanosoma cruzi infected rats did not cause ultrastructural morphologic changes on enterochromaffin-like (ECL) cells of the stomach, although it induced a significant increase of the gastric secretion. Our data seem to indicate that gastric ECL cells structure is not affected by stimulation with scorpion toxin or by acute infection with...
Influência do BCG no controle da imunodeficiência humoral induzida pelo mastoci...
Bräscher,H. M.; Vargens,J. R.; Maia,L. C. S.; Lima,A. OliveiraO BCG, em solução lipídica, injetado por via intravenosa, foi capaz de reverter a imunosupressão humoral provocada pelo mastocitoma P-815, em camundongos singênicos DBA/2, aumentando tanto o número de células formadoras de placas hemolíticas quanto os títulos de anticorpos hemaglutinantes do soro. Não foram encontradas diferenças significativas nos títulos de anticorpos hemaglutinantes da classe IgG. Nenhum efe...
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