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Motor-Independent Targeting of CLASPs to Kinetochores by CENP-E Promotes Microt...
Maffin, Stefano; Maia, Ana R. R.; Manning, Amity L.; Maliga, Zoltan; Pereira, Ana L.; Junqueira, Magno; Shevchenko, Andrej; Hyman, AnthonyEfficient chromosome segregation during mitosis relies on the coordinated activity of molecular motors with proteins that regulate kinetochore attachments to dynamic spindle microtubules [1]. CLASPs are conserved kinetochore- and microtubule-associated proteins encoded by two paralogue genes, clasp1 and clasp2, and have been previously implicated in the regulation of kinetochore-microtubule dynamics [2-4]. Howe...
Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the tra...
Efimov, Andrey; Kharitonov, Alexey; Efimova, Nadia; Loncarek, Jadranka; Miller, Paul M.; Andreyeva, Natalia; Gleeson, Paul; Galjart, NielsProper organization of microtubule arrays is essential for intracellular trafficking and cell motility. It is generally assumed that most if not all microtubules in vertebrate somatic cells are formed by the centrosome. Here we demonstrate that a large number of microtubules in untreated human cells originate from the Golgi apparatus in a centrosome-independent manner. Both centrosomal and Golgi-emanating micro...
Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating ...
Pereira, Ana L.; Pereira, António J.; Maia, Ana R.R.; Drabek, Ksenija; Sayas, C. Laura; Hergert, Polla J.; Lince-Faria, Mariana; Matos, IrinaCLASPs are widely conserved microtubule plus-end–tracking proteins with essential roles in the local regulation of microtubule dynamics. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present, which is required for mitotic spindle assembly by regulating microtubule dynamics at the kinetochore. In mammals, however, only CLASP1 has been directly implicated in cell division, despite the existence ...
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