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CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-mic...
Manning, Amity L; Bakhoum, Samuel F.; Maffini, Stefano; Melo, Clara C; Maiato, Helder; Compton, Duane AAccurate chromosome segregation during mitosis requires precise coordination of various processes such as chromosome alignment, maturation of proper kinetochoremicrotubule (kMT) attachments, correction of erroneous attachments, and silencing of the spindle assembly checkpoint (SAC). How these fundamental aspects of mitosis are coordinately and temporally regulated is poorly understood. Here we show that the tem...
Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator
Lince-Faria, Mariana; Maffini, Stefano; Orr, Bernard; Ding, Yun; Florindo, Cláudia; Sunkel, Claudio E.; Tavares, Álvaro; Johansen, JørgenA putative spindle matrix has been hypothesized to mediate chromosome motion, but its existence and functionality remain controversial. In this report, we show that Megator (Mtor), the Drosophila melanogaster counterpart of the human nuclear pore complex protein translocated promoter region (Tpr), and the spindle assembly checkpoint (SAC) protein Mad2 form a conserved complex that localizes to a nuclear derived...
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