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Rapeseed oil‑rich diet alters hepatic mitochondrial membrane lipid composition ...

Diet is directly related with physiological alterations occurring at a cell and subcellular level. However, the role of diet manipulation on mitochondrial physiology is still largely unexplored. Aiming at correlating diet with alterations of mitochondrial membrane composition and bioenergetics, Wistar-Han male rats were fed for 11, 22 and 33 days with a rapeseed oil-based diet and mitochondrial bioenergetics, a...

Lipidomic approach of the biological activity of tacrine and two tacrine-analog...

Tacrine and its analogues impair mitochondrial function and bioenergetics : a l...

Tacrine is an acetylcholinesterase inhibitor used as cognitive enhancer in Alzheimer's disease treatment. However, the low therapeutic efficiency and the high incidence of side effects have limited its clinical use. In the present study, the molecular mechanisms underlying the brain activity of tacrine and two novel tacrine analogues (T1, T2) were approached focusing on three aspects: i) effects on brain cholin...

Gestão integrada de redes de comunicação : estrutura da informação

Dissertação apresentada para obtenção do grau de Mestre em Engenharia Electrotécnica e de Computadores, na Faculdade de Engenharia da Universidade do Porto, sob a orientação do Prof. Doutor José António Ruela Simões Fernandes