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An inelastic neutron scattering study of dietary phenolic acids
Marques, M. P. M.; Batista de Carvalho, Luís A. E.; Valero, Rosendo; Machado, Nelson F. L.; Parker, Stewart F.The conformational preferences and hydrogen-bonding motifs of several potential chemopreventive hydroxycinnamic derivatives were determined by inelastic neutron scattering spectroscopy. The aim is to understand their recognized beneficial activity and establish reliable structure–activity relationships for these types of dietary phytochemicals. A series of phenolic acids with different hydroxyl/methoxyl ring su...
New sustained release of Zidovudine Matrix tablets − cytotoxicity toward Caco-2...
Santos, Jucimary V.; Pina, Maria Eugénia T.; Marques, M. P. M.; Batista de Carvalho, Luís A. E.Objective: The aim of this study was to adjust the zidovudine (AZT) release from solid tablets to an ideal profile, by developing matrices comprising swellable polymers with nonswellable ones. Methods: Directly compressed matrices comprised different ratios of hydroxypropylmethylcellulose K15M and K100M, ethylcellulose, and methacrylic acid (Eudragit® RS PO and Eudragit® RL PO) were prepared. Technological char...
Applying vibrational spectroscopy to the study of nucleobases – adenine as a ca...
Lopes, Rui P.; Valero, Rosendo; Tomkinson, John; Marques, M. P. M.; Batista de Carvalho, Luís A. E.A full conformational study of solid-state anhydrous adenine is reported, using vibrational spectroscopy techniques coupled to DFT calculations, for the isolated molecule and the solid. In both cases, the N9Hamino tautomer was found to be the predominant species, followed by the N7H-amino form. An excellent agreement was achieved between experiment and theory, both for wavenumbers and intensities (without the n...
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