Schistosoma haematobium is a parasitic flatworm that infects millions of people, mostly in the developing world, and is associated with high incidence of bladder cancer although why is not clear. But our group was able to define the mechanistic relationship for the first time between infection of S. haematobium and cancer. We used in vitro models to demonstrate the presence of informative carcinogenesis-associa...
Epidermal growthf actor (EGF) plays a critical role in cancer. A polymorphism in the EGF gene (EGF+61) may influence its expression and contribute to cancer predisposition and aggressiveness. In the present study, we aimed to elucidate the role of EGF+61in glioma susceptibility and prognosis. Experimental Design:A case-control study involving197 glioma patients and 570 controlswas done. Univariate and multivari...
Nesta dissertação pretendemos, através do confronto de várias ideologias e conceitos – quer epocais quer da nossa contemporaneidade –, inferir do leitmotiv que esteve na base da escrita da Peregrinação de Fernão Mendes Pinto e de que forma ela é (dis)semelhante da realidade e da ideologia da época. Nesta linha, procurámos discernir quais os mitos, símbolos e forças motrizes que a enformaram e enformam, ainda, o...
Approximately 30% of all hereditary diffuse gastric cancer (HDGC) families carry CDH1 germline mutations. The other two thirds remain genetically unexplained and are probably caused by alterations in other genes. Using polymerase chain reaction (PCR)/single-strand conformation polymorphism (SSCP)/sequencing, we screened 32 Portuguese families with a history of gastric cancer and 23 patients with early onset gas...
Dissertação de Doutoramento em Biologia Humana apresentada à Faculdade de Medicina da Universidade do Porto
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