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A synthetic biology approach to engineer "therapeutic" bacteria
Duarte, S. O. D.; Paulo, J.; Machado, C. D.; Rocha, I.; Mergulhão, Filipe; Rodrigues, L. R.; Monteiro, G. A.The high incidence and mortality of solid tumors like breast cancer makes the development of novel therapeutic agents a high priority. Curcumin, a natural substance from the rhizome of Curcuma longa, has captured the attention of the scientific community. Pre-clinical trials and extensive research has demonstrated its ability to prevent cancer. Indeed, curcumin has been shown to target critical genes involved i...
Synbiobacther : engineering “therapeutic” bacteria
Rodrigues, L. R.; Rodrigues, J.; Machado, C. D.; Kluskens, Leon; Mota, M.; Rocha, I.; Ferreira, E. C.SYNBIOBACTHER – Engineering “therapeutic” bacteria Rodrigues LR, Rodrigues JL, Machado CD, Kluskens L, Mota M, Rocha I, Ferreira EC IBB-Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal Statistics show that over 1.3 million persons will be diagnosed with breast cancer worldwide this year, hence this is an enormou...
An approach towards genome-scale kinetic modelling : application to the Escheri...
Costa, R. S.; Machado, C. D.; Rocha, I.; Ferreira, E. C.Understanding the dynamic behavior of living organisms is a great challenge in systems biology. To address this, computational dynamic modeling of metabolic networks is essential to guide experimentation and to explain properties of complex biological systems. Large-scale kinetic models at the reaction network level are usually constructed using mechanistic enzymatic rate equations and a large number of kinetic...
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