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Cognitive Decline of Medicamentous Etiology

In the elderly there is a high risk of inappropriate medication and adverse effects of polypharmacy. A 68 year-old female patient resorted to the Emergency Room for suspected stroke. According to the husband, in the six months prior to admission, she became progressively disorientated and dependent. She had resorted to various appointments from different specialties and was polymedicated. It was impossible to c...

Genetic screening of Alzheimer's disease genes in Iberian and African samples y...

Mutations in three genes (PSEN1, PSEN2, and APP) have been identified in patients with early-onset (<65years) Alzheimer’s disease (AD). We performed a screening for mutations in the coding regions of presenilins, as well as exons 16 and 17 of the APP gene in a total of 231 patients from the Iberian peninsular with a clinical diagnosis of early onset AD (mean age at onset of 52.9 years; range 31– 64). We found t...

Isolated oculomotor nerve paresis as the presenting sign of multiple sclerosis

O iberismo e a França como cultura intermediária em Oliveira Martins

pp. 89-95 ; Cerca de trinta anos depois, alguns textos dispersos mas significativos em termos teóricos dum outro historiador português, representante da chamada geração de 70, Oliveira Martins, transformam esta rígida, demasiado solene e um tanto abstracta heroicidade lusitana oposta à hegemonia espanhola em ampla visão cultural ibérica. E essa transformação processa- se através sobretudo duma cultura latina i...