Development of streptomycin-resistance in Mycobacterium tuberculosis is usually associated with mutations in rpsL and rrs genes, although up to 50% of clinical streptomycin-resistant isolates may present no mutation in either of these genes. The situation in Lisbon Health Region is similar, although mutations in rrs gene are only rarely detected. In the present report we investigate the role of gidB gene mutati...
Multidrug- (MDR) and extensively drug resistant (XDR) tuberculosis (TB) present a challenge to disease control and elimination goals. Lisbon, Portugal, has a high TB incidence rate and, unusual and successful XDR-TB strains that are found in circulation for almost two decades. In the present study, 56 Mycobacterium tuberculosis isolates, mostly recovered in Lisbon, were genotyped by 24-loci Mycobacterial Inters...
Em Portugal, e de acordo com o último relatório do Programa Nacional de luta contra a Tuberculose da Direção-Geral da Saúde, em 2012 foram notificados 2480 casos de tuberculose (TB), dos quais 2286 correspondem a casos novos (taxa de incidência de 21,6/100.000 habitantes). Embora Portugal continue entre os países de incidência intermédia, o único na Europa Ocidental, a incidência dos casos novos parece vir a di...
Development of streptomycin-resistance in Mycobacterium tuberculosis is usually associated with mutations in rpsL and rrs genes, although up to 50% of clinical streptomycin-resistant isolates may present no mutation in either of these genes. The situation in Lisbon Health Region is similar, although mutations in rrs geneare only rarely detected. In the present report we investigate the role of gidB gene mutatio...
Abstrat publicado em: http://www.pasteur.fr/infosci/conf/sb/tuberculosis2012/images/TB2012-Program-Abstract-book-LD.pdf ; The development of multidrug-resistant (MDR) and extensive drug-resistant (XDR) tuberculosis(TB) combined with subsequent transmission constitutes a serious threat to the effective control of tuberculosis in several countries. Lisbon Health Region, despite great progresses in TB management ...
This thesis is devoted to exact solution methods for NP-hard integer programming models. We consider two of these problems, the cutting stock problem and the vehicle routing problem. Both problems have been studied for several decades by researchers and practitioners of the Operations Research eld. Their interest and contribution to real-world applications in business, industry and several kinds of organizatio...
Monografia apresentada à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Licenciada em Medicina Dentária ; Este estudo teve como objectivo avaliar: quantitativamente, as variações na determinação de cinco medidas cefalométricas (quatro angulares e uma linear), a partir de uma telerradiografia lateral, analisada por sessenta observadores, que tiveram que determinar, previamente, ...
Dissertação para obtenção do Grau de Doutor em Conservação e Restauro, ramo de Teoria, História e Técnicas da Produção ArtÃstica ; A dissertação que aqui se apresenta partiu da necessidade de colocar em confronto as bases éticas da conservação e restauro, que assentam na defesa da materialidade histórica, com a progressiva desmaterialização da arte que ocorre a partir da década de 60 em dia...
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