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Association of statin therapy with blood pressure control in hypertensive hype...
Morgado, Manuel; Rolo, Sandra; Macedo, Ana Filipa; Castelo-Branco, MiguelBackground: Some clinical evidence revealed that statins, apart from lowering cholesterol levels, also have an antihypertensive effect. Our aim was to evaluate the existence of a possible association of statin therapy with blood pressure (BP) control in clinical practice. Materials and Methods: Patients attending a hypertension/ dyslipidemia clinic were prospectively evaluated. Those patients with a diagno...
Predictors of uncontrolled hypertension and antihypertensive medication nonadhe...
Morgado, Manuel; Rolo, Sandra; Macedo, Ana Filipa; Pereira, Luísa; Castelo-Branco, Miguelhttp://www.jcdronline.com/text.asp?2010/1/4/196/74263 ; Background: Although hypertension is, in most cases, a controllable major risk factor in the development of cardiovascular disease, studies have demonstrated that hypertension remains poorly controlled in Portugal. Our aim was to evaluate the covariates associated with poor blood pressure (BP) control in a Portuguese hypertensive population. Patients a...
Causality assessment of adverse drug reactions: comparison of the results obtai...
Macedo, Ana Filipa; Marques, Francisco Batel; Ribeiro, Carlos Fontes; Teixeira, FredericoTo compare the results of causality assessments of reported adverse drug reactions (ADR's) obtained from decisional algorithms with those obtained from an expert panel using the WHO global introspection method (GI) and to further evaluate the influence of confounding variables on algorithms ability in assessing causality.Two hundred sequentially reported ADR's were included in this study. An independent researc...
Desenvolvimento e validação de um instrumento de avaliação da imputabilidade de...
Macedo, Ana Filipa Pereira Amaral deINTRODUÇÃO A avaliação do nexo de causalidade entre uma suspeita de reacção adversa e a exposição a um medicamento é critica em Farmacovigilância, particularmente pelas suas implicações no balanço benefício-risco de medicamentos. Diferentes algoritmos têm sido propostos para esta avaliação. Nenhum algoritmo é aceite como referência, reconhecendo-se a necessidade de uma análise comparativa de todas as estratégia...
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