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Urinary Estrogen Metabolites and Self-Reported Infertility in Women Infected wi...

Schistosomiasis is a neglected tropical disease, endemic in 76 countries, that afflicts more than 240 million people. The impact of schistosomiasis on infertility may be underestimated according to recent literature. Extracts of Schistosoma haematobium include estrogen-like metabolites termed catechol-estrogens that down regulate estrogen receptors alpha and beta in estrogen responsive cells. In addition, schis...

Silk Fibroin/Nano-CaP Bilayered scaffolds for osteochondral tissue engineering

In this study, bilayered silk and silk/nano-CaP scaffolds were developed for osteochondral (OC) tissue engineering. Aqueous silk solution (16 wt.%) was used for preparation of the cartilage-like layer and, for generation of the silk/nano-CaP suspension and the bottom layer (CaP/Silk: 16 wt.%). The scaffolds were formed by using salt-leaching/lyophilization approach. The scanning electron microscopy revealed tha...

A comprehensive assessment of the transcriptome of cork oak (Quercus suber) thr...

Background: Cork oak (Quercus suber) is one of the rare trees with the ability to produce cork, a material widely used to make wine bottle stoppers, flooring and insulation materials, among many other uses. The molecular mechanisms of cork formation are still poorly understood, in great part due to the difficulty in studying a species with a long life-cycle and for which there is scarce molecular/genomic inform...

Metformina: causa ou coincidência?

Ryanodine myopathies without central cores-clinical, histopathologic, and genet...

BACKGROUND: Mutations in ryanodine receptor 1 gene (RYR1) are frequent causes of myopathies. They classically present with central core disease; however, clinical variability and histopathologic overlap are being increasingly recognized. PATIENTS: Patient 1 is a 15-year-old girl with mild proximal, four-limb weakness from age 5, presenting with a progressive scoliosis starting at age 10. Patient 2 is an 18-yea...

Development of a novel methodology for the analysis of ergosterol in mushrooms

Sterols are important molecules in the unsaponifiable fraction of several matrices. Ergosterol, which is an important vitamin D2 precursor, is clearly the main sterol in mushrooms. Herein, an analytical method for ergosterol determination in cultivated and wild mushrooms was developed using high-performance liquid chromatography coupled to ultraviolet detection. The chromatographic separation was achieved in an...

Medical Image Registration: a Review

This paper presents a review of automated image registration methodologies that have been used in the medical field. The aim of this paper is to be an introduction to the field, provide knowledge on the work that has been developed and to be a suitable reference for those who are looking for registration methods for a specific application. The registration methodologies under review are classified into intensit...

A robust computational solution for automated quantification of a specific bind...

Aim The purpose of the current paper is to present a computational solution to accurately quantify a specific to a non-specific uptake ratio in [123I] FP-CIT single photon emission computed tomography (SPECT) images and simultaneously measure the spatial dimensions of the basal ganglia, also known as basal nuclei. A statistical analysis based on a reference dataset selected by the user is also automatically per...

A Path- and Label-cost Propagation Approach to speedup the Training of the Opti...

In general, pattern recognition techniques require a high computational burden for learning the discriminating functions that are responsible to separate samples from distinct classes. As such, there are several studies that make effort to employ machine learning algorithms in the context of "big data" classification problems. The research on this area ranges from Graphics Processing Units-based implementations...

Automated segmentation of the incus and malleus ossicles in conventional tri-di...

This paper proposes a fully automated computational solution to segment the incus and malleus ear ossicles in conventional tri-dimensional (3D) X-ray computed tomography (CT) images. The solution uses a registration-based segmentation paradigm, followed by image segmentation refinement. It was tested against a dataset comprising 21 CT volumetric images of the ear acquired using standard protocols and with resol...