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NOD2 gene mutations in ulcerative colitis: useless or misunderstood?

PURPOSE: NOD2 mutations have been linked to an increased risk of Crohn's disease and to some of its phenotypes. The association between NOD2 mutations and susceptibility to ulcerative colitis (UC) remains somewhat controversial and potential correlations between these mutations and UC phenotype have not been studied. AIM: To assess whether NOD2 mutations are a risk factor for UC in Portugal and if there are any...

EBSD Study of Fe-Ni phases on a L4-L5 ordinary chondrite meteorite

The research on interplanetary materials such as comets, meteors or meteorites contributes to understand the origin and evolution of our Solar System. They provide highly valuable information on the relation between the conditions of formation and their microstructure, chemical composition and magnetic properties. Orientation relationships of the Fe-Ni system and distribution of body-centered cubic kamacite-α,...

Alterações do pH no diagnostico das intoxicações

Biocompatibility of poly(lactic acid) with incorporated graphene-based materials

The incorporation of graphene-based materials has been shown to improve mechanical properties of poly(lactic acid) (PLA). In this work, PLA films and composite PLA films incorporating two graphene-based materials – graphene oxide (GO) and graphene nanoplatelets (GNP) – were prepared and characterized regarding not only biocompatibility, but also surface topography, chemistry and wettability. The presence of bot...

Silk-Fibroin/Methacrylated Gellan Gum Hydrogel as an novel scaffold for applica...

Introduction: Knee meniscus injury is highly prevalent and there is a demand for new cost-effective treatment solutions. Tissue engineering (TE) and regenerative medicine strategies using acellular scaffolds are being used in clinical application for total or partial meniscus replacement [1]. Although this strategy has been considered as a safe and promising approach, progressive volume reduction of the implant...

Avaliação experimental do comportamento sísmico de casas de madeira

As casas de madeira estão a ter um desenvolvimento rápido na Europa devido a aspetos tais como a sustentabilidade e o elevado grau de industrialização e prefabricação, que se traduzem em facilidade e rapidez de montagem. Os sistemas mais tradicionais de estruturas de madeira e os sistemas inovadores recentes são agora aplicados não apenas no norte da Europa mas, crescentemente, no sul da Europa, onde a perigosi...

Effect of chitosan-based solutions applied as edible coatings and water glazing...

The aim of this research was to compare the effect of chitosan solutions on frozen salmon preservation with that of water glazing. For this purpose, three chitosan solutions (0.25%, 0.50% and 0.75% w/v) and water were applied in different amounts (6%, 8% and 11% of coated fillet weight) directly on the surface of frozen salmon. In order to accelerate the deterioration processes, salmon was stored during 14 week...

Distinct behavior between multi-antibiotic resistant escherichia coli strains t...

Advanced mimetic materials for meniscus tissue engineering : targeting segmenta...

Meniscus lesions are among the most common orthopaedic injuries which can ultimately lead to degeneration of the knee articular cartilage. The human meniscus has a limited healing potential, partly due to a poor vasculature, and thus meniscus regeneration using tissue engineering strategies has recently been investigated as a promising alternative to total/partial meniscectomy [1]. Advanced scaffolds for tissue...

In vitro and in vivo biological performance of modified gellan gum-based hydrog...

Ionic- (iGG-MA) and photo-crosslinked (phGG-MA) methacrylated gellan gum hydrogels have been proposed as biomaterials for supporting nucleus pulposus (NP) regeneration and/or repair. In this study, the mechanical stability and biocompatibility of these hydrogels have been evaluated in vitro. Human intervertebral disc cells obtained from herniated patients were cultured within both hydrogels, for 1–21 days. Dyna...