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The role of Helicobacter pylori outer membrane proteins in adherence and pathog...
Oleastro, Mónica; Ménard, ArmelleHelicobacter pylori is one of the most successful human pathogens, whichcolonizes the mucus layer of the gastric epithelium of more than 50% of the world’spopulation. This curved, microaerophilic, Gram-negative bacterium induces a chronicactive gastritis, often asymptomatic, in all infected individuals. In some cases, this gastritisevolves to more severe diseases such as peptic ulcer disease, gastric adenocarci...
Positive selection in the evolution of Helicobacter pylori outer membrane proteins
Nunes, Alexandra; Ménard, Armelle; Mégraud, Francis; Oleastro, MónicaHomologous recombination in Helicobacter pylori has been extensively described to occur via Outer Membrane Proteins (OMPs), regulating protein expression and generating allelic diversity, while the importance of single nucleotide polymorphisms (SNP) remains little studied. We used an OMP-encoding gene, homC, as a model to evaluate the weight of positive selection in the evolution of H. pylori, by using G200 seq...
Diversity and phylogeny of the Helicobacter pylori outer membrane protein-encod...
Cordeiro, Rita; Ménard, Armelle; Breurec, Stéphane; Mégraud, Francis; Oleastro, MónicaThe genetic diversity and evolution of the homC gene was evaluated in a panel of approximately 200 clinical and reference strains, isolated from patients from different geographical origins and presenting different gastric diseases. PCR, sequencing and bioinformatics analyses were used. All the strains tested harboured a complete homC gene at a conserved locus. Phylogenetic reconstruction of homC showed a geogr...
High worldwide conservation of a Helicobacter pylori outer membrane protein
Ménard, Armelle; Cordeiro, Rita; Breurec, Stéphane; Mégraud, Francis; Oleastro, MónicaThe genetic diversity and evolution of homD, coding for Helicobacter pylori outer membrane protein (OMP) was investigated in a panel of approximately 200 clinical and reference strains, isolated from patients from different geographical origins and presenting different gastric diseases. PCR, sequencing and bioinformatics analyses were used. The homD gene was present in all strains, at a conserved locus, and sho...
Allelic Diversity among Helicobacter pylori Outer Membrane Protein Genes homB a...
Oleastro, Mónica; Cordeiro, Rita; Ménard, Armelle; Gomes, João PauloRecombination is one of the main mechanisms contributing to Helicobacter pylori genomic variability. homB and homA are paralogous genes coding for H. pylori outer membrane proteins (OMPs). Both genes display allelic variation yielded by polymorphisms of the genes’ middle regions, with six different alleles. This study used bioinformatic and statistical analyses to evaluate whether the allelic diversity of homB ...
Clinical relevance and diversity of two homologous genes encoding glycosyltrans...
Oleastro, Mónica; Andrea, Santos; Cordeiro, Rita; Nunes, Baltazar; Mégraud, Francis; Ménard, ArmelleHelicobacter pylori is known to be a major cause of peptic ulceration. The jhp0562 gene, encoding a glycosyltransferase involved in the synthesis of the lipopolysaccharide, was associated with peptic ulcer disease (PUD) in children. The beta-(1,3)-galactosyltransferase [beta-(1,3)GalT] gene (jhp0563), involved in Lewis (Le) antigen expression, is highly similar to jhp0562. The clinical significance and diversit...
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