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H5dotasa (=(alphaRS)-alpha-(carboxymethyl)-1,4,7,10-tetraazacyclododecane-1,4,7...
André, João P.; Brücher, Ernö; Kiraly, Robert; Carvalho, Rui A.; Mäcke, Helmut; Geraldes, Carlos F. G. C.The ligand H5dotasa (=(alphaRS)-alpha-(carboxymethyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) is a H4dota-like macrocyclic ligand with a carboxymethyl CH2COOH substituent at the C(alpha) atom of one of the four acetate pendant arms of H4dota (=1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), present as a racemic mixture of (alphaR) and (alphaS) enantiomers. The protonation constants ...
DOTASA, an Asymmetrical Derivative of DOTA Substituted at one Acetate pendant A...
André, João P.; Brücher, Ernö; Kiraly, Robert; Carvalho, Rui A.; Mäcke, Helmut; Geraldes, Carlos F. G. C.The ligand H5dotasa (=(alphaRS)-alpha-(carboxymethyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) is a H4dota-like macrocyclic ligand with a carboxymethyl CH2COOH substituent moiety at the C(alpha) atom of one of the four acetate pendant arms of H4dota (=1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), present as a racemic mixture of (alphaR) and (alphaS) enantiomers. The protonation con...
DOTASA revisited : 1H NMR and potentiometric studies of a highly asymmetrical l...
André, João P.; Kiraly, Robert; Carvalho, Rui A.; Mäcke, Helmut; Geraldes, Carlos F. G. C.; Brücher, ErnöPoster apresentado no 8th FIGIPAS Meeting in Inorganic Chemistry, Atenas, Grécia, 6 - 9 Jul. 2005. ; DOTASA (1,4,7,10-tetraazacyclodo-decane-1-(R,S)-succinic acid-4,7,10-triacetic acid) is a DOTA-like macrocyclic ligand showing a carboxymethyl -CH2COOH substituent moiety at a C carbon of one of the four acetate pendant arms, present as a racemic mixture of R and S configurations.The protonation constants of t...
NMR spectroscopy of Group 13 metal ions : biologically relevant aspects
André, João P.; Mäcke, HelmutReview ; In spite of the fact that Group 13 metal ions (Al(III), Ga(III), In(III) and Tl(I)/(III)) show no main biological role, they are NMR-active nuclides which can be used in magnetic resonance spectroscopy of biologically relevant systems. The fact that these metal ions are quadrupolar (with the exception of thallium) means that they are particularly sensitive to ligand type and coordination geometry. The...
NODAGATOC, a New Chelator-Coupled Somatostatin Analogue Labeled with [67/68Ga] ...
Eisenwiener, Klaus-Peter; Prata, M. I. M.; Buschmann, I.; Zhang, Han-Wen; Santos, A. C.; Wenger, Sandra; Reubi, Jean Claude; Mäcke, Helmut R.A monoreactive NOTA (1,4,7-triazacyclononane-1,4,7-triacetic acid) derived prochelator (1-(1-carboxy-3-carbo-tert-butoxypropyl)-4,7-(carbo-tert-butoxymethyl)-1,4,7-triazacyclononane (NODAGA(tBu)3)) was synthesized in five steps with an overall yield of 21%. It is useful for the coupling to the N-terminus of peptides on solid phase and in solution; it was coupled to [Tyr3]-octreotide (TOC) on solid phase, and th...
IN VIVO and IN VITRO 27AI NMR studies of aluminium(III) chelates of triazacyclo...
André, João P.; Mäcke, Helmut; Kaspar, Armin; Kunnecke, BasilThe metallic radioisotope of a known radiopharmaceutical chelate, 67Ga(NOTA) (NOTA=1,4,7-triazacyclonane-1,4,7-triacetic acid), used for tumor detection, was substituted by the chemically similar but non radioactive aluminum ion. Our aim was to detect and evaluate the in vivo behavior of the chelate. For this purpose, Al(NOTA) and the related chelate Al(NODASA) (NODASA=1,4,7-triazacyclononane-1-succinic acid-4,...
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