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Nanostructured polymeric coatings based on chitosan and dopamine-modified hyalu...

In a marine environment, specific proteins are secreted by mussels and used as a bioglue to stick to a surface. These mussel proteins present an unusual amino acid 3,4-dihydroxyphenylalanine (known as DOPA). The outstanding adhesive properties of these materials in the sea harsh conditions have been attributed to the presence of the catechol groups present in DOPA. Inspired by the structure and composition of t...

Polymeric layer-by-layer films composed by natural polymers and based on the ad...

Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; Some marine species, such as mussels, can strongly attach themselves to rocks in the diffficult conditions of the sea. In fact, marine mussels secrete adhesive proteins that show a high adhesion to both inorganic and organic surfaces in aqueous environments. These proteins have an amino acid designated as 3,4-dihyd...

Micropatterning of bioactive glass nanoparticles on chitosan membranes for spat...

Bioactive glass nanoparticles (BG-NPs) capable of inducing apatite precipitation upon immersion in simulated body fluid (SBF) were patterned on free-standing chitosan membranes by microcontact printing using a poly(dimethylsiloxane) (PDMS) stamp inked in a BG-NPs pad. Formation of the patterns was characterized by scanning electron microscopy (SEM). Mineralization of the bioactive glass patterns was induced in ...

Bioactive glass nanoparticles combined with natural-based polymers for biomedic...

Programa Doutoral em Engenharia Biomédica ; Bone tissue engineering has assisted in the last decades to an evolution in which merely replacement implants gave room to more complex regenerative approaches. Several challenges still remain. Although biocompatibility and biodegradability mechanism are now reasonably known and controlled, they still need to precisely match the physiological rhythm of bone renewal, ...

Cell behaviour in new poly(l-lactic acid) films with crystallinity gradients

We report a new facile method for the development of crystallinity gradients in poly(l-lactic acid) films, based on the gradual dipping of amorphous PLLA samples in a hot bath. Isothermal cold crystallization studies were performed using DSC and optical microscopy in order to find adequate conditions to generate crystallinity gradients in the PLLA films. Cellular response along PLLA samples with graded spheruli...

Chitosan/bioactive glass nanoparticle composite membranes for periodontal regen...

Barrier membranes are used in periodontal applications with the aim of supporting periodontal regeneration by physically blocking migration of epithelial cells. The present work proposes a combination of chitosan (CHT) with bioactive glass nanoparticles (BG-NPs) in order to produce a novel guided tissue and bone regeneration membrane, fabricated by solvent casting. The CHT/BG-NP nanocomposite membranes are char...

Preparation and characterization of bioactive glass nanoparticles prepared by s...

Bioactive glass nanoparticles (BG-NPs), based on both ternary (SiO(2)-CaO-P(2)O(5)) and binary (SiO(2)-CaO) systems, were prepared via an optimized sol-gel method. The pH of preparation and the effect of heat treatment temperature were evaluated, as well as the effect of suppressing P in the bioactivity ability of the materials. The morphology and composition of the BG-NPs were studied using FTIR, XRD and SEM. ...

Micropatterning of bioactive glass nanoparticles on chitosan membranes for spat...