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Molecular mechanisms of the metabolite 4-hydroxytamoxifen of the anticancer dru...
Monteiro, J. P.; Martins, J. D.; Luxo, P. C.; Jurado, A. S.; Madeira, V. M. C.A strain of the thermophilic eubacterium Bacillus stearothermophilus was used as a model system to identify membrane mediated cytotoxic effects of 4-hydroxytamoxifen, following previous studies with tamoxifen. With this experimental approach we attempted to further clarify tamoxifen and 4-hydroxytamoxifen membrane interactions often evoked as responsible for their multiple cellular effects. Bacterial growth and...
Data: 2003
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Origem: Estudo Geral - Universidade de Coimbra
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