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Toxicity assessment of tamoxifen by means of a bacterial model
Luxo, Cristina; Jurado, Amália; Madeira, VítorAbstract A strain of Bacillus stearothermophilus was used as a model to study physical perturbations induced in the membrane by the cytostatic tamoxifen (TAM). This study was carried out using two lines of criteria: (1) bacterial growth, and temperature growth range, with determination of growth parameters as a function of TAM concentration; and (2) biophysical studies by differential scanning calorimetry (DSC...
Lipid composition changes induced by tamoxifen in a bacterial model system
Luxo, Cristina; Jurado, Amália S.; Madeira, Vítor M. C.A putative relationship between growth impairment of Bacillus stearothermophilus by tamoxifen (TAM) and TAM-induced perturbation of the physical properties of bacterial membrane lipids has been observed. The supplementation of the growth medium with Ca2+ (a membrane stabilizer) partially relieves growth inhibition by TAM, allowing growth at TAM concentrations that fully impair growth in the basal medium. B. ste...
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