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Triple Therapy with High-Dose Proton-Pump Inhibitor, Amoxicillin, and Doxycycli...
Almeida, N; Romãozinho, JM; Donato, MM; Luxo, C; Cardoso, O; Cipriano, MA; Marinho, C; Sofia, CINTRODUCTION: Helicobacter pylori resistance to antibiotics is steadily increasing and multidrug-resistant strains are common and difficult to eliminate, mainly in countries where bismuth, tetracycline, furazolidone, and rifabutin are unavailable. AIM: To evaluate the efficacy and safety of a triple therapy with proton-pump inhibitor (PPI), amoxicillin, and doxycycline in patients with multidrug-resistant H. py...
Tamoxifen induces ultrastructural alterations in membranes of Bacillus Stearoth...
Luxo, C.; Jurado, A. S.; Madeira, Vítor M. C.; Silva, M. T.Tamoxifen (TAM), a non-steroid antiestrogen, is the mostly used drug for chemotherapy and chemoprevention of breast cancer. However, the mechanisms by which TAM inhibits cell proliferation in breast cancer are not fully understood. TAM strongly incorporates in biomembranes and a variety of effects have been assigned to biophysical and biochemical interactions with membranes. Therefore, a better understanding of...
Toxic effects of tamoxifen on the growth and respiratory activity of Bacillus s...
Luxo, C.; Jurado, A. S.; Custódio, J. B. A.; Madeira, V. M. C.The anticancer drug tamoxifen (TAM) is used as first line therapy in breast cancer. Although tamoxifen is usually considered an estrogen antagonist, several studies suggest alternative mechanisms of action. Bacillus stearothermophilus has been used as a model to clarify the antiproliferative action of tamoxifen putatively related with drug-membrane interaction. According to previous data, TAM induces perturbati...
Cytotoxicity and Membrane Interaction of Tamoxifen as Affected by Ca2+ and Mg2+...
Luxo, C.; Jurado, A. S.; Madeira, V. M. C.A strain of Bacillus stearothermophilus was used as a model to study the interaction of tamoxifen (TAM) with the membrane and the cytostatic antiproliferative effects not related to estrogen binding. TAM inhibits the growth of B. stearothermophilus as a function of concentration. The supplementation of the growth medium with Ca2+ or Mg2+ partially relieves the growth inhibition by TAM, allowing growth at TAM co...
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